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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2,4,5,10,11,14,19,20 are 12
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3139
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    88 percent target mRNA inhibition
    18637735
    SM3141
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    85 percent target mRNA inhibition
    18637735
    SM3142
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    81 percent target mRNA inhibition
    18637735
    SM3146
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    65 percent target mRNA inhibition
    18637735
    SM3157
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18637735
    SM3159
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    78 percent target mRNA inhibition
    18637735
    SM3160
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    78 percent target mRNA inhibition
    18637735
    SM3164
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    47 percent target mRNA inhibition
    18637735
    SM3175
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    55 percent target mRNA inhibition
    18637735
    SM3177
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3178
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3182
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    3 percent target mRNA inhibition
    18637735