Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2,4,6,8,10,12,14,16,18 are 34
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2251
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    61 percent target mRNA inhibition
    16598842
    SM2252
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Phosphate
    Phosphate
    74 percent target mRNA inhibition
    16598842
    SM2535
    UCUUGAUGUACUCCCCUCG
    CGAGGGGAGUACAUCAAGA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    NA
    12771196
    SM2537
    UCUUGAUGUACUCCCCUCG
    CGAGGGGAGUACAUCAAGA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    NA
    12771196
    SM2540
    AAUUCCAGUGGUUCAUUCC
    GGAAUGAACCACUGGAAUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    NA
    12771196
    SM2541
    AAUUCCAGUGGUUCAUUCC
    GGAAUGAACCACUGGAAUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    NA
    12771196
    SM3132
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    18637735
    SM3134
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    83 percent target mRNA inhibition
    18637735
    SM3135
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    91 percent target mRNA inhibition
    18637735
    SM3150
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    18637735
    SM3152
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    76 percent target mRNA inhibition
    18637735
    SM3153
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    95 percent target mRNA inhibition
    18637735
    SM3168
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3170
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3171
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    66 percent target mRNA inhibition
    18637735
    SM3185
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    31 percent target mRNA inhibition
    18637735
    SM3187
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3191
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3193
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3197
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3199
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    29 percent target mRNA inhibition
    18637735
    SM3395
    CCACCACAGCUAGAACUUA
    GGUGGUGUCGAUCUUGAAU
    2-Fluoro
    2-Fluoro
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    NA
    16625242
    SM3396
    CCACCACAGCUAGAACUUA
    UAAGUUCUAGCUGUGGUGG
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    NA
    16625242
    SM3398
    CCACCACAGCUAGAACUUA
    UAAGUUCUAGCUGUGGUGG
    2-O-Methyl
    2-O-Methyl* Cy3
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19 * 19
    Sugar
    Sugar
    NA
    16625242
    SM3399
    CCAACUUCACCAUCCAGAA
    UUCUGGAUGGUGAAGUUGG
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    NA
    16625242