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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


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• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 2,8,14,17 are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0003	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-O-Methyl	2,8,14,17 2	Sugar Sugar	54.2 percent target mRNA inhibition	19282453
SM0049	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-O-Methyl* 2-Aminoethyl	2,8,14,17 1 * 21	Sugar Sugar	70 percent target mRNA inhibition	19282453
SM0094	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-O-Methyl* 2-Cyanoethyl	2,8,14,17 1 * 18	Sugar Sugar	47.8 percent target mRNA inhibition	19282453
SM0139	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid Altritol nucleic acid	2,8,14,17 1,2	Sugar Sugar	60.1 percent target mRNA inhibition	19282453
SM0184	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	2,8,14,17 20,21	Sugar Sugar	82.8 percent target mRNA inhibition	19282453
SM0229	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	2,8,14,17 5,8,11,14,17,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0274	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid Altritol nucleic acid	2,8,14,17 3,6,14,18,20,21	Sugar Sugar	29.6 percent target mRNA inhibition	19282453
SM0319	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	2,8,14,17 18,19,20 * 21	Sugar Sugar	63.5 percent target mRNA inhibition	19282453
SM0364	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	2,8,14,17 2,18,19,20 * 21	Sugar Sugar	39.2 percent target mRNA inhibition	19282453
SM0409	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	2,8,14,17 3,18,19,20 * 21	Sugar Sugar	50.6 percent target mRNA inhibition	19282453
SM0454	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid Hexitol nucleic acid* 2-Deoxy	2,8,14,17 2,9,18,19,20 * 21	Sugar Sugar	9.4 percent target mRNA inhibition	19282453
SM0499	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	2,8,14,17 18,19 * 21	Sugar Sugar	16.9 percent target mRNA inhibition	19282453
SM0544	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	Hexitol nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	2,8,14,17 18,19 * 21	Sugar Sugar	1.9 percent target mRNA inhibition	19282453
SM0589	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-Fluoro* 2-O-Methyl	2,8,14,17 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	7.8 percent target mRNA inhibition	19282453
SM0634	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	2,8,14,17 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0679	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	2,8,14,17 4,18	Sugar Sugar	25.8 percent target mRNA inhibition	19282453
SM0724	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	2,8,14,17 3,4,18	Sugar Sugar	42.7 percent target mRNA inhibition	19282453
SM0769	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	2,8,14,17 3,18	Sugar Sugar	33 percent target mRNA inhibition	19282453
SM0814	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	2,8,14,17 4,18	Sugar Sugar	7.6 percent target mRNA inhibition	19282453
SM0859	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	2,8,14,17 3,4,18	Sugar Sugar	57.9 percent target mRNA inhibition	19282453
SM0904	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	2,8,14,17 3,18	Sugar Sugar	4.2 percent target mRNA inhibition	19282453
SM0949	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	2,8,14,17 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0994	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	Hexitol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	2,8,14,17 3,4,18	Sugar Sugar	44.4 percent target mRNA inhibition	19282453
SM1039	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-Aminoethyl	2,8,14,17 20,21	Sugar Sugar	85 percent target mRNA inhibition	19282453
SM1084	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	Hexitol nucleic acid 2-Aminopropyl	2,8,14,17 1	Sugar Sugar	59.3 percent target mRNA inhibition	19282453



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