SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2163 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-Deoxy 2-Deoxy |
20,21 20,21 |
Sugar Sugar |
74 percent target mRNA inhibition | 22411910 |
SM2166 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-O-Methyl-4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,4,16,17,18,19 * 20,21 20,21 |
Sugar Sugar |
60 percent target mRNA inhibition | 22411910 |
SM2167 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-O-Methyl-4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,4,18,19 * 20,21 20,21 |
Sugar Sugar |
66 percent target mRNA inhibition | 22411910 |
SM2168 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-O-Methyl-4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,4 * 20,21 20,21 |
Sugar Sugar |
64 percent target mRNA inhibition | 22411910 |
SM2169 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-O-Methyl-4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,17,18,19 * 20,21 20,21 |
Sugar Sugar |
80 percent target mRNA inhibition | 22411910 |
SM2170 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
2-O-Methyl-4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,17,18,19 * 20,21 20,21 |
Sugar Sugar |
IC-50 = 26.3 nM for target mRNA | 22411910 |
SM2171 |
GCGCUGCUGGUGCCAACCCTT GGGUUGGCACCAGCAGCGCTT |
4-Thioribose* 2-Deoxy 2-Deoxy |
1,2,3,17,18,19 * 20,21 20,21 |
Sugar Sugar |
IC-50 = 29.2 nM for target mRNA | 22411910 |
SM2984 |
GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT |
0 2-Deoxy |
0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
0 Sugar |
0 percent target mRNA inhibition | 12923253 |
SM2986 |
GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT |
2-Deoxy 2-Deoxy |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
Sugar Sugar |
0 percent target mRNA inhibition | 12923253 |
SM4720 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
2-Deoxy 2-Deoxy |
20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | US 8653252 B2 |
SM4723 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
Locked nucleic acid 2-Deoxy |
20,21 20,21 |
Sugar Sugar |
96 percent target mRNA inhibition | US 8653252 B2 |
SM4726 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
5-Methylcytosine* Locked nucleic acid 2-Deoxy |
1 * 20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | US 8653252 B2 |
SM4729 |
CTTACGCTGAGTACTTCGATT UCGAAGUACUCAGCGUAAGTT |
5-Methylcytosine* Locked nucleic acid 2-Deoxy |
1 * 2,3,8,12,15,16,20,21 20,21 |
Sugar Sugar |
80 percent target mRNA inhibition | US 8653252 B2 |
SM4732 |
AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT |
2-Deoxy 2-Deoxy |
20,21 20,21 |
Sugar Sugar |
95 percent target mRNA inhibition | US 8653252 B2 |
SM4739 |
CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT |
2-Deoxy 2-Deoxy |
20,21 20,21 |
Sugar Sugar |
96 percent target mRNA inhibition | US 8653252 B2 |
SM4742 |
TGAGAGAAAGCACAGAAAATT UUUUCUGUGCUUUCUCUCATT |
Locked nucleic acid 2-Deoxy |
1,20,21 20,21 |
Sugar Sugar |
70 percent target mRNA inhibition | US 8653252 B2 |
SM4743 |
TGAGAGAAAGCACAGAAAATT UGAGAGAAAGCACAGAAAATT |
Locked nucleic acid 2-Deoxy |
1,3,5,9,12,14,17,20,21 20,21 |
Sugar Sugar |
64 percent target mRNA inhibition | US 8653252 B2 |