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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for 2-Deoxy are 17
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2163
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    74 percent target mRNA inhibition
    22411910
    SM2166
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4,16,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    60 percent target mRNA inhibition
    22411910
    SM2167
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4,18,19 * 20,21
    20,21
    Sugar
    Sugar
    66 percent target mRNA inhibition
    22411910
    SM2168
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,4 * 20,21
    20,21
    Sugar
    Sugar
    64 percent target mRNA inhibition
    22411910
    SM2169
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    22411910
    SM2170
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-O-Methyl-4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    IC-50 = 26.3 nM for target mRNA
    22411910
    SM2171
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    4-Thioribose* 2-Deoxy
    2-Deoxy
    1,2,3,17,18,19 * 20,21
    20,21
    Sugar
    Sugar
    IC-50 = 29.2 nM for target mRNA
    22411910
    SM2984
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2986
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    2-Deoxy
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM4720
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4723
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2
    SM4726
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4729
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 2,3,8,12,15,16,20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    US 8653252 B2
    SM4732
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4739
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2
    SM4742
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    2-Deoxy
    1,20,21
    20,21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    US 8653252 B2
    SM4743
    TGAGAGAAAGCACAGAAAATT
    UGAGAGAAAGCACAGAAAATT
    Locked nucleic acid
    2-Deoxy
    1,3,5,9,12,14,17,20,21
    20,21
    Sugar
    Sugar
    64 percent target mRNA inhibition
    US 8653252 B2