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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 2-Guanidinoethyl are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0002	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-O-Methyl	18 2	Sugar Sugar	76.8 percent target mRNA inhibition	19282453
SM0048	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-O-Methyl* 2-Aminoethyl	18 1 * 21	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0093	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-O-Methyl* 2-Cyanoethyl	18 1 * 18	Sugar Sugar	55 percent target mRNA inhibition	19282453
SM0138	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl Altritol nucleic acid	18 1,2	Sugar Sugar	56.1 percent target mRNA inhibition	19282453
SM0183	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 20,21	Sugar Sugar	88.8 percent target mRNA inhibition	19282453
SM0228	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 5,8,11,14,17,20	Sugar Sugar	19.2 percent target mRNA inhibition	19282453
SM0273	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl Altritol nucleic acid	18 3,6,14,18,20,21	Sugar Sugar	78.4 percent target mRNA inhibition	19282453
SM0318	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 18,19,20 * 21	Sugar Sugar	84.8 percent target mRNA inhibition	19282453
SM0363	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 2,18,19,20 * 21	Sugar Sugar	78.5 percent target mRNA inhibition	19282453
SM0408	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 3,18,19,20 * 21	Sugar Sugar	78.5 percent target mRNA inhibition	19282453
SM0453	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl Hexitol nucleic acid* 2-Deoxy	18 2,9,18,19,20 * 21	Sugar Sugar	42.2 percent target mRNA inhibition	19282453
SM0498	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl 2-Aminoethoxymethyl* 2-Deoxy	18 18,19 * 21	Sugar Sugar	49.1 percent target mRNA inhibition	19282453
SM0543	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGT	2-Guanidinoethyl 2-Aminopropoxymethyl* 2-Deoxy	18 18,19 * 21	Sugar Sugar	36.2 percent target mRNA inhibition	19282453
SM0588	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-Fluoro* 2-O-Methyl	18 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	81.1 percent target mRNA inhibition	19282453
SM0633	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	18 3,18	Sugar Sugar	55 percent target mRNA inhibition	19282453
SM0678	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	18 4,18	Sugar Sugar	23.3 percent target mRNA inhibition	19282453
SM0723	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	18 3,4,18	Sugar Sugar	88.7 percent target mRNA inhibition	19282453
SM0768	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	18 3,18	Sugar Sugar	81.8 percent target mRNA inhibition	19282453
SM0813	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	18 4,18	Sugar Sugar	80.3 percent target mRNA inhibition	19282453
SM0858	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	18 3,4,18	Sugar Sugar	88.8 percent target mRNA inhibition	19282453
SM0903	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	18 3,18	Sugar Sugar	77.5 percent target mRNA inhibition	19282453
SM0948	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	18 4,18	Sugar Sugar	81.4 percent target mRNA inhibition	19282453
SM0993	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGC	2-Guanidinoethyl 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	18 3,4,18	Sugar Sugar	77.3 percent target mRNA inhibition	19282453
SM1038	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-Aminoethyl	18 20,21	Sugar Sugar	88.9 percent target mRNA inhibition	19282453
SM1083	GACGUAAACGGCCACAAGUUC ACUUGUGGCCGUUUACGUCGCU	2-Guanidinoethyl 2-Aminopropyl	18 1	Sugar Sugar	55.3 percent target mRNA inhibition	19282453



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