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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for 2-O-(2-Methoxyethyl) are 3
Results from 0 - 25
SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2281 |
AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU |
2-O-(2-Methoxyethyl) 0 |
1,2,3,17,18,19 0 |
Sugar 0 |
IC-50 = 0.58 nM for target mRNA | 16509579 |
SM2282 |
AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU |
2-O-(2-Methoxyethyl) 4-Thioribose |
1,2,3,17,18,19 1,2,18,19 |
Sugar Sugar |
IC-50 = 0.66 nM for target mRNA | 16509579 |
SM2284 |
AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU |
2-O-(2-Methoxyethyl) 4-Thioribose* 2-O-Methyl |
1,2,3,17,18,19 1,2 * 17,18,19 |
Sugar Sugar |
IC-50 = 0.2 nM for target mRNA | 16509579 |