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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-O-Methyl are 502
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2197
    GCAGCACGACUUCUUCAAGUU
    CUUGAAGAAGUCGUGCUGCUU
    2-O-Methyl
    0
    2
    0
    Sugar
    0
    71.74 percent target mRNA inhibition
    18575806
    SM2198
    GCAGCACGACUUCUUCAAGUU
    CUUGAAGAAGUCGUGCUGCUU
    2-O-Methyl
    2-O-Methyl
    2
    2
    Sugar
    Sugar
    62.72 percent target mRNA inhibition
    18575806
    SM2199
    GCAGCACGACUUCUUCAAGUU
    UUCGUCGUGCUGAAGAAGUUC
    2-O-Methyl
    2-Fluoro
    2
    2
    Sugar
    Sugar
    77.23 percent target mRNA inhibition
    18575806
    SM2202
    UAGUUCUGUGGGGCUGUUUUU
    AAACAGCCCCACAGAACUAUU
    2-O-Methyl
    2-Fluoro
    2
    2
    Sugar
    Sugar
    NA
    18575806
    SM2243
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3
    1,2,3
    Sugar
    Sugar
    60 percent target mRNA inhibition
    16598842
    SM2244
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    17,18,19
    17,18,19
    Sugar
    Sugar
    73 percent target mRNA inhibition
    16598842
    SM2245
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,17,18,19
    1,2,3,17,18,19
    Sugar
    Sugar
    76 percent target mRNA inhibition
    16598842
    SM2246
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,6,7,8,12,13,14,17,18,19
    1,2,3,6,7,8,12,13,14,17,18,19
    Sugar
    Sugar
    45 percent target mRNA inhibition
    16598842
    SM2247
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    4,5,9,10,11,15,16
    1,2,3,6,7,8,12,13,14,17,18,19
    Sugar
    Sugar
    38 percent target mRNA inhibition
    16598842
    SM2248
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,3,5,7,9,11,13,15,17,19
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    75 percent target mRNA inhibition
    16598842
    SM2249
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,3,5,7,9,11,13,15,17,19
    2,4,6,8,10,12,14,16,18,
    Sugar
    Sugar
    65 percent target mRNA inhibition
    16598842
    SM2250
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18,
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    16598842
    SM2251
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Sugar
    Sugar
    61 percent target mRNA inhibition
    16598842
    SM2253
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    18,19
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842
    SM2254
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Phosphate
    76 percent target mRNA inhibition
    16598842
    SM2255
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    29 percent target mRNA inhibition
    16598842
    SM2256
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    71 percent target mRNA inhibition
    16598842
    SM2257
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19
    Sugar
    Sugar
    37 percent target mRNA inhibition
    16598842
    SM2260
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    53 percent target mRNA inhibition
    16598842
    SM2261
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    74 percent target mRNA inhibition
    16598842
    SM2262
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro* Inverted DeoxyThymidine
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19 *21
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842
    SM2487
    CAGCAAACCACGAUCAAUATT
    UAUUGAUCGUGGUUUGCUGTT
    2-O-Methyl
    2-O-Methyl
    1,4,8,9,11,14,15,18
    1,3,4,7,8,10,13,14,15,17,18
    Sugar
    Sugar
    5 percent target mRNA inhibition
    22889374
    SM2490
    CAGAGCAAUUGUUUACCUATT
    UAGGUAAACAAUUGCUCUGTT
    2-O-Methyl
    2-O-Methyl
    1,6,9,10,12,13,14,16,17,18
    1,5,9,12,13,15,16,17
    Sugar
    Sugar
    75 percent target mRNA inhibition
    22889374
    SM2518
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196
    SM2519
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    2-O-Methyl
    3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,20
    3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    Low mRNA target inhibition efficacy
    12771196