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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-O-methoxyethylribose are 6
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4756
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-methoxyethylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,18
    5,8,11,14,17,18,19
    Sugar
    Sugar
    IC-50 = 0.47593 nM for target mRNA
    US 8394947 B2
    SM4757
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-methoxyethylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,19
    6,7,10,11,17,18,19
    Sugar
    Sugar
    IC-50 = 0.11759 nM for target mRNA
    US 8394947 B2
    SM4787
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    2-O-methoxyethylribose
    2-O-methoxyethylribose
    2,4,6,8,10,12,14,16,18
    4,8,16
    Sugar
    Sugar
    50 percent target mRNA inhibition
    US 8394947 B2
    SM4795
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    2-O-methoxyethylribose
    2-O-methoxyethylribose
    2,4,6,8,10,12,14,18
    4,10,19
    Sugar
    Sugar
    70 percent target mRNA inhibition
    US 8394947 B2
    SM4796
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    2-O-methoxyethylribose
    2-O-methoxyethylribose
    4,9,14,18
    4,10,19
    Sugar
    Sugar
    80 percent target mRNA inhibition
    US 8394947 B2
    SM4799
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    2-O-methoxyethylribose
    2-O-methoxyethylribose
    4,9,14,18
    4,8,16
    Sugar
    Sugar
    40 percent target mRNA inhibition
    US 8394947 B2