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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 20 are 83
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0020
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-O-Methyl
    20
    2
    Sugar
    Sugar
    80 percent target mRNA inhibition
    19282453
    SM0066
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Aminoethyl
    20
    1 * 21
    Sugar
    Sugar
    83 percent target mRNA inhibition
    19282453
    SM0111
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Cyanoethyl
    20
    1 * 18
    Sugar
    Sugar
    55.5 percent target mRNA inhibition
    19282453
    SM0156
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    20
    1,2
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    19282453
    SM0201
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    20
    20,21
    Sugar
    Sugar
    88.3 percent target mRNA inhibition
    19282453
    SM0246
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    20
    5,8,11,14,17,20
    Sugar
    Sugar
    12.2 percent target mRNA inhibition
    19282453
    SM0291
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    Altritol nucleic acid
    20
    3,6,14,18,20,21
    Sugar
    Sugar
    80.8 percent target mRNA inhibition
    19282453
    SM0336
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    Hexitol nucleic acid* 2-Deoxy
    20
    18,19,20 * 21
    Sugar
    Sugar
    85.9 percent target mRNA inhibition
    19282453
    SM0381
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    Hexitol nucleic acid* 2-Deoxy
    20
    2,18,19,20 * 21
    Sugar
    Sugar
    79 percent target mRNA inhibition
    19282453
    SM0426
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    Hexitol nucleic acid* 2-Deoxy
    20
    3,18,19,20 * 21
    Sugar
    Sugar
    82.3 percent target mRNA inhibition
    19282453
    SM0471
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    Hexitol nucleic acid* 2-Deoxy
    20
    2,9,18,19,20 * 21
    Sugar
    Sugar
    49.8 percent target mRNA inhibition
    19282453
    SM0516
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    2-Aminoethoxymethyl* 2-Deoxy
    20
    18,19 * 21
    Sugar
    Sugar
    57.5 percent target mRNA inhibition
    19282453
    SM0561
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    2-Aminoethyl
    2-Aminopropoxymethyl* 2-Deoxy
    20
    18,19 * 21
    Sugar
    Sugar
    42.7 percent target mRNA inhibition
    19282453
    SM0606
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-Fluoro* 2-O-Methyl
    20
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    Sugar
    Sugar
    79.2 percent target mRNA inhibition
    19282453
    SM0651
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    20
    3,18
    Sugar
    Sugar
    58.8 percent target mRNA inhibition
    19282453
    SM0696
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    20
    4,18
    Sugar
    Sugar
    12.9 percent target mRNA inhibition
    19282453
    SM0741
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    20
    3,4,18
    Sugar
    Sugar
    88.9 percent target mRNA inhibition
    19282453
    SM0786
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    20
    3,18
    Sugar
    Sugar
    81.9 percent target mRNA inhibition
    19282453
    SM0831
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    20
    4,18
    Sugar
    Sugar
    76.6 percent target mRNA inhibition
    19282453
    SM0876
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    20
    3,4,18
    Sugar
    Sugar
    89.1 percent target mRNA inhibition
    19282453
    SM0921
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    3,18
    Sugar
    Sugar
    78.9 percent target mRNA inhibition
    19282453
    SM0966
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    4,18
    Sugar
    Sugar
    81.2 percent target mRNA inhibition
    19282453
    SM1011
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    3,4,18
    Sugar
    Sugar
    77.9 percent target mRNA inhibition
    19282453
    SM1056
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    20
    20,21
    Sugar
    Sugar
    89.7 percent target mRNA inhibition
    19282453
    SM1101
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    20
    1
    Sugar
    Sugar
    62 percent target mRNA inhibition
    19282453