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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 21,22,23,24,25 are 16
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2423
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    62 percent target mRNA inhibition
    23449220
    SM2426
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    5-Fluoro-2-Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    62 percent target mRNA inhibition
    23449220
    SM2427
    GGAUAUUGUCAGUCUUUAGGAAAAA
    CCUAAAGACUGACAAUAUCCUUUUU
    Deoxyadenine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    31 percent target mRNA inhibition
    23449220
    SM2428
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCUUUUU
    5-Fluoro-2-Deoxyuridine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    NA
    23449220
    SM2429
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    5-Fluoro-2-Deoxyuridine* Deoxyadenine
    21,22,23,24,25
    10,16,18 * 21,22,23,24,25
    Sugar
    Sugar
    0 percent target mRNA inhibition
    23449220
    SM2430
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    5-Fluoro-2-Deoxyuridine* Deoxyadenine
    21,22,23,24,25
    16,18 * 21,22,23,24,25
    Sugar
    Sugar
    25 percent target mRNA inhibition
    23449220
    SM2431
    GGAUAUUGUCAGUCUUUAGGAAAAA
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyadenine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    NA
    23449220
    SM2432
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    NA
    23449220
    SM2436
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    13 percent target mRNA inhibition
    23449220
    SM2437
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    5-Fluoro-2-Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    15 percent target mRNA inhibition
    23449220
    SM2438
    GGAUAUUGUCAGUCUUUAGGAAAAA
    CCUAAAGACUGACAAUAUCCUUUUU
    Deoxyadenine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    68 percent target mRNA inhibition
    23449220
    SM2439
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCUUUUU
    5-Fluoro-2-Deoxyuridine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    35 percent target mRNA inhibition
    23449220
    SM2442
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    23449220
    SM2443
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCAAAAA
    5-Fluoro-2-Deoxyuridine
    Deoxyadenine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    83 percent target mRNA inhibition
    23449220
    SM2444
    GGAUAUUGUCAGUCUUUAGGAAAAA
    CCUAAAGACUGACAAUAUCCUUUUU
    Deoxyadenine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    54 percent target mRNA inhibition
    23449220
    SM2445
    GGAUAUUGUCAGUCUUUAGGUUUUU
    CCUAAAGACUGACAAUAUCCUUUUU
    5-Fluoro-2-Deoxyuridine
    5-Fluoro-2-Deoxyuridine
    21,22,23,24,25
    21,22,23,24,25
    Sugar
    Sugar
    60 percent target mRNA inhibition
    23449220