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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 21141919 are 25
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4427	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	2-Deoxyribonucleotide 2-Deoxyribonucleotide	20,21 20,21	Base Base	36 percent target mRNA inhibition	21141919
SM4428	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	[1,1-Biphenyl]-3,5-dimethanol [1,1-Biphenyl]-3,5-dimethanol	20,21 20,21	Base Base	43 percent target mRNA inhibition	21141919
SM4429	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol	20,21 20,21	Base Base	30 percent target mRNA inhibition	21141919
SM4430	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	[3-(hydroxymethyl)-5-phenanthren-9-ylphenyl]methanol [3-(hydroxymethyl)-5-phenanthren-9-ylphenyl]methanol	20,21 20,21	Base Base	22 percent target mRNA inhibition	21141919
SM4431	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	[3-(hydroxymethyl)-5-pyren-1-ylphenyl]methanol [3-(hydroxymethyl)-5-pyren-1-ylphenyl]methanol	20,21 20,21	Base Base	0 percent target mRNA inhibition	21141919
SM4432	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	Fluorescein* 2-Deoxyribonucleotide 2-Deoxyribonucleotide	1 * 21,22 20,21	Base Base	NA	21141919
SM4433	GGCCUUUCACUACUCCUACTT GUAGGAGUAGUGAAAGGCCTT	Fluorescein* [1,1-Biphenyl]-3,5-dimethanol [1,1-Biphenyl]-3,5-dimethanol	1 * 21,22 21,22	Base Base	NA	21141919
SM4434	CUUCUUCGUCGAGACCAUGTT CAUGGUCUCGACGAAGAAGTT	2-Deoxyribonucleotide 2-Deoxyribonucleotide	20,21 20,21	Base Base	45 percent target mRNA inhibition	21141919
SM4435	CUUCUUCGUCGAGACCAUGTT CAUGGUCUCGACGAAGAAGTT	[1,1-Biphenyl]-3,5-dimethanol* 2-Deoxyribonucleotide 2-Deoxyribonucleotide	1 * 20,21 20,21	Base Base	45 percent target mRNA inhibition	21141919
SM4436	CUUCUUCGUCGAGACCAUGTT CAUGGUCUCGACGAAGAAGTT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide 2-Deoxyribonucleotide	1 * 20,21 20,21	Base Base	25 percent target mRNA inhibition	21141919
SM4437	CUUCUUCGUCGAGACCAUGTT CAUGGUCUCGACGAAGAAGTT	2-Deoxyribonucleotide [1,1-Biphenyl]-3,5-dimethanol* 2-Deoxyribonucleotide	20,21 1 * 21,22	Base Base	34 percent target mRNA inhibition	21141919
SM4438	CUUCUUCGUCGAGACCAUGTT CAUGGUCUCGACGAAGAAGTT	2-Deoxyribonucleotide [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide	20,21 1 * 21,22	Base Base	25 percent target mRNA inhibition	21141919
SM4439	UUUCACUACUCCUACGAGCTT GCUCGUAGGAGUAGUGAAATT	2-Deoxyribonucleotide 2-Deoxyribonucleotide	20,21 20,21	Base Base	0 percent target mRNA inhibition	21141919
SM4440	UUUCACUACUCCUACGAGCTT GCUCGUAGGAGUAGUGAAATT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol	1 * 20,21 20,21	Base Base	67 percent target mRNA inhibition	21141919
SM4441	UUUCACUACUCCUACGAGCTT GCUCGUAGGAGUAGUGAAATT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol	1 * 20,21 20,21	Base Base	43 percent target mRNA inhibition	21141919
SM4442	UUUCACUACUCCUACGAGCTT GCUCGUAGGAGUAGUGAAATT	5-O-methylthymidine 2-Deoxyribonucleotide	1 20,21	Base Base	31 percent target mRNA inhibition	21141919
SM4443	UAAGAUGUUCAUCGAGUCCTT GGACUCGAUGAACAUCUUATT	2-Deoxyribonucleotide 2-Deoxyribonucleotide	20,21 20,21	Base Base	0 percent target mRNA inhibition	21141919
SM4444	UAAGAUGUUCAUCGAGUCCTT GGACUCGAUGAACAUCUUATT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol	1 * 21,22 20 * 21	Base Base	58 percent target mRNA inhibition	21141919
SM4445	UAAGAUGUUCAUCGAGUCCTT GGACUCGAUGAACAUCUUATT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol	1 * 21,22 21,22	Base Base	71 percent target mRNA inhibition	21141919
SM4446	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	2-Deoxyribonucleotide 2-Deoxyribonucleotide	21,22 20,21	Base Base	NA	21141919
SM4447	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	[3-(hydroxymethyl)phenyl]methanol 1,3-Benzenedimethanol	21,22 20,21	Base Base	NA	21141919
SM4448	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol	1 * 22,23 21 * 22	Base Base	NA	21141919
SM4449	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol 1,3-Benzenedimethanol	1 * 22,23 21,22	Base Base	NA	21141919
SM4450	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	[3-(hydroxymethyl)phenyl]methanol [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 1,3-Benzenedimethanol	21,22 21 * 22	Base Base	NA	21141919
SM4451	GUCUCGUAGACCGUGCAUCATT UGAUGCACGGUCUACGAGACTT	[3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide* [3-(hydroxymethyl)phenyl]methanol 2-Deoxyribonucleotide*  [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* [3-(hydroxymethyl)phenyl]methanol	1 * 7,11,14,18 * 22,23 4,8,11,15 * 21 * 22	Base Base	NA	21141919