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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 21687525 are 24
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2909
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2910
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2911
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid* Small internally segmented RNA
    Locked nucleic acid
    3,9,13,15,20,21 * 14
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2912
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2913
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2914
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3
    0
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2917
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2918
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2919
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid* Small internally segmented RNA
    Locked nucleic acid
    3,9,13,15,20,21 * 14
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2920
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2921
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2922
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3
    0
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2925
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2926
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2927
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid* Small internally segmented RNA
    Locked nucleic acid
    3,9,13,15,20,21 * 14
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2928
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2929
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2930
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3
    0
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2933
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2934
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2935
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid* Small internally segmented RNA
    Locked nucleic acid
    3,9,13,15,20,21 * 14
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2936
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGUU
    UnLocked nucleic acid
    Unlocked nucleic acid
    21
    21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2937
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2938
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    0
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    0
    3
    0
    Sugar
    High target mRNA inhibition efficacy
    21687525