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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22253019 are 360
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4958
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.95 percent target mRNA inhibition
    22253019
    SM4959
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    12 percent target mRNA inhibition
    22253019
    SM4960
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.82 percent target mRNA inhibition
    22253019
    SM4961
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Deoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    88.15 percent target mRNA inhibition
    22253019
    SM4962
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    97.14 percent target mRNA inhibition
    22253019
    SM4963
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    80.8 percent target mRNA inhibition
    22253019
    SM4964
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 3,4,5,6,7,8,9,10,15,18,19,20,21 * 1,2,11,12,13,14,16,17
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    96.65 percent target mRNA inhibition
    22253019
    SM4965
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 20,21 * 3,4,5,6,7,8,9,10,15,18,19
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar
    96.85 percent target mRNA inhibition
    22253019
    SM4966
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Hydroxy* 2-Methoxy* 2-Fluoro
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,11,12,13,14,16,17 * 20,21 * 3,4,5,6,7,8,9,10,15,18,19
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    95.64 percent target mRNA inhibition
    22253019
    SM4967
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* 2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Phosphate; Sugar; Sugar; Sugar
    94.35 percent target mRNA inhibition
    22253019
    SM4968
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 *20,21
    Base; Sugar; Sugar
    Sugar
    97.62 percent target mRNA inhibition
    22253019
    SM4969
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    0 percent target mRNA inhibition
    22253019
    SM4970
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    96.02 percent target mRNA inhibition
    22253019
    SM4971
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21 * 14
    Base; Sugar; Sugar
    Sugar
    84.92 percent target mRNA inhibition
    22253019
    SM4972
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    97.53 percent target mRNA inhibition
    22253019
    SM4973
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    91.55 percent target mRNA inhibition
    22253019
    SM4974
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19,20,21
    Base; Sugar; Sugar
    Sugar
    96.84 percent target mRNA inhibition
    22253019
    SM4975
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    97.16 percent target mRNA inhibition
    22253019
    SM4976
    CCAGUAAGGCUUCUCUUAAUU
    TTAAGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19 * 20,21
    Base; Sugar; Sugar
    Sugar
    95.29 percent target mRNA inhibition
    22253019
    SM4977
    CCAGUAAGGCUUCUCUUAAUU
    UUAAGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    2-Methoxy* 2-Fluoro* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1,2,11,12,13,16,17,20,21 * 3,4,5,6,7,8,9,10,15,18,19 * 14
    Base; Sugar; Sugar
    Sugar
    94.21 percent target mRNA inhibition
    22253019
    SM4978
    CCAGUAAGGCUUCUCUUAAUU
    AGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    79.75 percent target mRNA inhibition
    22253019
    SM4979
    CCAGUAAGGCUUCUCUUAAUU
    AGAGAAGCCTTACTGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    0.11 percent target mRNA inhibition
    22253019
    SM4980
    CCAGUAAGGCUUCUCUUAAUU
    AGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    93.3 percent target mRNA inhibition
    22253019
    SM4981
    CCAGUAAGGCUUCUCUUAAUU
    AGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Methoxy* 2-Hydroxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1* 1,2,3,4,5,6,7,8,9,10,12,13,14,15,16,17,18 * 11
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar
    0 percent target mRNA inhibition
    22253019
    SM4982
    CCAGUAAGGCUUCUCUUAAUU
    AGAGAAGCCUUACUGGUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,2,3,4,5,6,7,12,15,16 * 8,9,10,11,13,14,17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    90.34 percent target mRNA inhibition
    22253019