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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 22260772 are 53
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4544	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	83 percent target mRNA inhibition	22260772
SM4545	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Sugar; Backbone Sugar	80 percent target mRNA inhibition	22260772
SM4546	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	51 percent target mRNA inhibition	22260772
SM4547	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1,14 * 20,21 20,21	Sugar; Backbone Sugar	23 percent target mRNA inhibition	22260772
SM4548	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	2 * 20,21 20,21	Sugar; Backbone Sugar	65 percent target mRNA inhibition	22260772
SM4549	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	7 * 20,21 20,21	Sugar; Backbone Sugar	73 percent target mRNA inhibition	22260772
SM4550	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	67 percent target mRNA inhibition	22260772
SM4551	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	38 percent target mRNA inhibition	22260772
SM4552	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	92 percent target mRNA inhibition	22260772
SM4553	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	91 percent target mRNA inhibition	22260772
SM4554	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	76 percent target mRNA inhibition	22260772
SM4555	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	86 percent target mRNA inhibition	22260772
SM4556	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	43 percent target mRNA inhibition	22260772
SM4557	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	49 percent target mRNA inhibition	22260772
SM4558	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	45 percent target mRNA inhibition	22260772
SM4559	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	91 percent target mRNA inhibition	22260772
SM4560	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Sugar; Backbone Sugar	86 percent target mRNA inhibition	22260772
SM4561	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	58 percent target mRNA inhibition	22260772
SM4562	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1,14 * 20,21 20,21	Sugar; Backbone Sugar	85 percent target mRNA inhibition	22260772
SM4563	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	2 * 20,21 20,21	Sugar; Backbone Sugar	88 percent target mRNA inhibition	22260772
SM4564	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	7 * 20,21 20,21	Sugar; Backbone Sugar	75 percent target mRNA inhibition	22260772
SM4565	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Sugar; Backbone Sugar	87 percent target mRNA inhibition	22260772
SM4566	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	93 percent target mRNA inhibition	22260772
SM4567	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	15 * 20,21 20,21	Sugar; Backbone Sugar	91 percent target mRNA inhibition	22260772
SM4568	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	94 percent target mRNA inhibition	22260772



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