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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 23135004 are 13
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2465
    CGGAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    21
    1
    NA
    NA
    60 percent target mRNA inhibition
    23135004
    SM2466
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    19
    1
    NA
    NA
    74 percent target mRNA inhibition
    23135004
    SM2467
    AGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    18
    1
    NA
    NA
    18 percent target mRNA inhibition
    23135004
    SM2468
    GGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    17
    1
    NA
    NA
    16 percent target mRNA inhibition
    23135004
    SM2469
    GCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    16
    1
    NA
    NA
    10 percent target mRNA inhibition
    23135004
    SM2470
    CUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Assymetric siRNA (3-End Overhang)
    Assymetric siRNA (3-End Overhang)
    15
    1
    NA
    NA
    14 percent target mRNA inhibition
    23135004
    SM2471
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 2,3,4,14,15,16,17 * 15,16,17
    0
    Phosphate; Base; Phosphate
    0
    48 percent target mRNA inhibition
    23135004
    SM2472
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* 2-O-Methyl* Fluorouridine* Phosphorothioate
    0
    1 * 1,2,3 * 15,16,17 * 19
    0
    Phosphate; Sugar; Base; Phosphate
    0
    58 percent target mRNA inhibition
    23135004
    SM2473
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 6,11,15,16,17 *19
    0
    Phosphate; Base; Phosphate
    0
    37 percent target mRNA inhibition
    23135004
    SM2474
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 15,16,17 * 1,2,19
    0
    Phosphate; Base; Phosphate
    0
    43 percent target mRNA inhibition
    23135004
    SM2475
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 6,11,15,16,17 * 2,3,19
    0
    Phosphate; Base; Phosphate
    0
    52 percent target mRNA inhibition
    23135004
    SM2476
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* 2-O-Methyl* Fluorouridine* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    1 * 1,2,3 * 15,16,17 * 19
    16 * 9,15,16,17,18,19,21
    Phosphate; Sugar; Base; Phosphate
    Sugar; Phosphate
    43 percent target mRNA inhibition
    23135004
    SM2477
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* 2-O-Methyl* Fluorouridine* Phosphorothioate
    2-O-Methyl* Phosphorothioate
    1 * 1,2,3 * 15,16,17 * 19
    2,8,16 * 21
    Phosphate; Sugar; Base; Phosphate
    Sugar; Phosphate
    13 percent target mRNA inhibition
    23135004