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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for 23344237 are 16
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4839
    GUCAUCACACUGAAUACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    DeoxyThymidine
    DeoxyThymidine
    23,24
    23,24
    Sugar
    Sugar
    60 percent target mRNA inhibition
    23344237
    SM4840
    GTCATCACACUGAAUACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* DeoxyThymidine
    DeoxyThymidine
    1,2,3,4,5 * 23,24
    23,24
    Sugar
    Sugar
    NA
    23344237
    SM4841
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* DeoxyThymidine
    DeoxyThymidine
    1,2,5,15,18 * 23,24
    23,24
    Sugar
    Sugar
    70 percent target mRNA inhibition
    23344237
    SM4842
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine
    DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24
    23,24
    Sugar
    Sugar
    50 percent target mRNA inhibition
    23344237
    SM4843
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    23,24
    Sugar
    Sugar
    20 percent target mRNA inhibition
    23344237
    SM4844
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2-Methoxyribose* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    13,15 * 23,24
    Sugar
    Sugar
    27 percent target mRNA inhibition
    23344237
    SM4845
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGTGTGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2,4-bridged nucleic acid* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    14,16* 23,24
    Sugar
    Sugar
    16 percent target mRNA inhibition
    23344237
    SM4846
    GUCAUCACACUGAAUACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    DeoxyThymidine* Cholesterol
    DeoxyThymidine
    23,24 * 24
    23,24
    Sugar
    Sugar
    NA
    23344237
    SM4847
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine
    DeoxyThymidine
    1,2,5,15,18 *3,4,6,7,16,17,19,20,21,22 * 23,24
    13,15 * 23,24
    Sugar
    Sugar
    NA
    23344237
    SM4848
    GUAUCUCUUCAUAGCCUUATT
    UAAGGCUAUGAAGAGAUACTT
    DeoxyThymidine
    DeoxyThymidine
    20,21
    20,21
    Sugar
    Sugar
    NA
    23344237
    SM4849
    GUCAUCACACUGAAUACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    DeoxyThymidine
    DeoxyThymidine
    23,24
    23,24
    Sugar
    Sugar
    95 percent target mRNA inhibition
    23344237
    SM4850
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* DeoxyThymidine
    DeoxyThymidine
    1,2,5,15,18 * 23,24
    23,24
    Sugar
    Sugar
    96 percent target mRNA inhibition
    23344237
    SM4851
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine
    DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24
    23,24
    Sugar
    Sugar
    78 percent target mRNA inhibition
    23344237
    SM4852
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    23,24
    Sugar
    Sugar
    75 percent target mRNA inhibition
    23344237
    SM4853
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2-Methoxyribose* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    13,15 * 23,24
    Sugar
    Sugar
    73 percent target mRNA inhibition
    23344237
    SM4854
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGTGTGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2,4-bridged nucleic acid* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    14,16* 23,24
    Sugar
    Sugar
    55 percent target mRNA inhibition
    23344237