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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

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• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 25699137 are 56
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4371	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	69 percent target mRNA inhibition	25699137
SM4372	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Phosphate ; Sugar Sugar	80 percent target mRNA inhibition	25699137
SM4373	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	1 * 2 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	43 percent target mRNA inhibition	25699137
SM4374	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	7 * 20,21 20,21	Phosphate ; Sugar Sugar	70 percent target mRNA inhibition	25699137
SM4375	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	7 * 8 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	86 percent target mRNA inhibition	25699137
SM4376	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	92 percent target mRNA inhibition	25699137
SM4377	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	9 * 10 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	50 percent target mRNA inhibition	25699137
SM4378	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine 2-Deoxythymidine	9 * 10 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	44 percent target mRNA inhibition	25699137
SM4379	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Phosphate ; Sugar Sugar	67 percent target mRNA inhibition	25699137
SM4380	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	14 * 15 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	67 percent target mRNA inhibition	25699137
SM4381	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine 2-Deoxythymidine	14 * 15 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	60 percent target mRNA inhibition	25699137
SM4382	CUUACGCUGAGUACUUCGAUU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Phosphate Sugar	93 percent target mRNA inhibition	25699137
SM4383	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	92 percent target mRNA inhibition	25699137
SM4384	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	85 percent target mRNA inhibition	25699137
SM4385	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine* Cholesterol 2-Deoxythymidine	1 * 20,21 20,21	Sugar ; Base Sugar	65 percent target mRNA inhibition	25699137
SM4386	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	89 percent target mRNA inhibition	25699137
SM4387	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 20,21	Phosphate ; Sugar Sugar	87 percent target mRNA inhibition	25699137
SM4388	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	1 * 2 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	85 percent target mRNA inhibition	25699137
SM4389	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	7 * 20,21 20,21	Phosphate ; Sugar Sugar	75 percent target mRNA inhibition	25699137
SM4390	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	7 * 8 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	95 percent target mRNA inhibition	25699137
SM4391	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	94 percent target mRNA inhibition	25699137
SM4392	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	9 * 10 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	90 percent target mRNA inhibition	25699137
SM4393	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine 2-Deoxythymidine	9 * 10 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	86 percent target mRNA inhibition	25699137
SM4394	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine 2-Deoxythymidine	14 * 20,21 20,21	Phosphate ; Sugar Sugar	88 percent target mRNA inhibition	25699137
SM4395	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine 2-Deoxythymidine	14 * 15 * 20,21 20,21	Phosphate ; Base ; Sugar Sugar	96 percent target mRNA inhibition	25699137



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