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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for 3,5,7,9,20,21 are 48
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0031
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,5,7,9,20,21
    2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0077
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,5,7,9,20,21
    1 * 21
    Sugar
    Sugar
    53 percent target mRNA inhibition
    19282453
    SM0122
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,5,7,9,20,21
    1 * 18
    Sugar
    Sugar
    3.2 percent target mRNA inhibition
    19282453
    SM0167
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    1,2
    Sugar
    Sugar
    2.2 percent target mRNA inhibition
    19282453
    SM0212
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    20,21
    Sugar
    Sugar
    85.6 percent target mRNA inhibition
    19282453
    SM0257
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    5,8,11,14,17,20
    Sugar
    Sugar
    2.5 percent target mRNA inhibition
    19282453
    SM0302
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    6.4 percent target mRNA inhibition
    19282453
    SM0347
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    3,5,7,9,20,21
    18,19,20 * 21
    Sugar
    Sugar
    52.7 percent target mRNA inhibition
    19282453
    SM0392
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    3,5,7,9,20,21
    2,18,19,20 * 21
    Sugar
    Sugar
    38.5 percent target mRNA inhibition
    19282453
    SM0437
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    3,5,7,9,20,21
    3,18,19,20 * 21
    Sugar
    Sugar
    18.7 percent target mRNA inhibition
    19282453
    SM0482
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    3,5,7,9,20,21
    2,9,18,19,20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0527
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    2-Aminoethoxymethyl* 2-Deoxy
    3,5,7,9,20,21
    18,19 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0572
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    Locked nucleic acid
    2-Aminopropoxymethyl* 2-Deoxy
    3,5,7,9,20,21
    18,19 * 21
    Sugar
    Sugar
    9 percent target mRNA inhibition
    19282453
    SM0617
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-Fluoro* 2-O-Methyl
    3,5,7,9,20,21
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0662
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    3,5,7,9,20,21
    3,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0707
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    3,5,7,9,20,21
    4,18
    Sugar
    Sugar
    3.6 percent target mRNA inhibition
    19282453
    SM0752
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    3,5,7,9,20,21
    3,4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0797
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    3,18
    Sugar
    Sugar
    0.4 percent target mRNA inhibition
    19282453
    SM0842
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0887
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    3,4,18
    Sugar
    Sugar
    19.5 percent target mRNA inhibition
    19282453
    SM0932
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    3,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0977
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM1022
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    3,4,18
    Sugar
    Sugar
    1.8 percent target mRNA inhibition
    19282453
    SM1067
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,5,7,9,20,21
    20,21
    Sugar
    Sugar
    84.6 percent target mRNA inhibition
    19282453
    SM1112
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,5,7,9,20,21
    1
    Sugar
    Sugar
    8.9 percent target mRNA inhibition
    19282453