| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0034 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-O-Methyl |
3,5,9,13,20,21
2 |
Sugar
Sugar |
56 percent target mRNA inhibition | 19282453 |
| SM0080 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-O-Methyl* 2-Aminoethyl |
3,5,9,13,20,21
1 * 21 |
Sugar
Sugar |
71.8 percent target mRNA inhibition | 19282453 |
| SM0125 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-O-Methyl* 2-Cyanoethyl |
3,5,9,13,20,21
1 * 18 |
Sugar
Sugar |
46.2 percent target mRNA inhibition | 19282453 |
| SM0170 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
Altritol nucleic acid |
3,5,9,13,20,21
1,2 |
Sugar
Sugar |
44.1 percent target mRNA inhibition | 19282453 |
| SM0215 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
Altritol nucleic acid |
3,5,9,13,20,21
20,21 |
Sugar
Sugar |
87.7 percent target mRNA inhibition | 19282453 |
| SM0260 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
Altritol nucleic acid |
3,5,9,13,20,21
5,8,11,14,17,20 |
Sugar
Sugar |
9.6 percent target mRNA inhibition | 19282453 |
| SM0305 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
Altritol nucleic acid |
3,5,9,13,20,21
3,6,14,18,20,21 |
Sugar
Sugar |
71.2 percent target mRNA inhibition | 19282453 |
| SM0350 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
3,5,9,13,20,21
18,19,20 * 21 |
Sugar
Sugar |
80.8 percent target mRNA inhibition | 19282453 |
| SM0395 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
3,5,9,13,20,21
2,18,19,20 * 21 |
Sugar
Sugar |
63.8 percent target mRNA inhibition | 19282453 |
| SM0440 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
3,5,9,13,20,21
3,18,19,20 * 21 |
Sugar
Sugar |
71.1 percent target mRNA inhibition | 19282453 |
| SM0485 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
3,5,9,13,20,21
2,9,18,19,20 * 21 |
Sugar
Sugar |
7.3 percent target mRNA inhibition | 19282453 |
| SM0530 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminoethoxymethyl* 2-Deoxy |
3,5,9,13,20,21
18,19 * 21 |
Sugar
Sugar |
35.7 percent target mRNA inhibition | 19282453 |
| SM0575 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
3,5,9,13,20,21
18,19 * 21 |
Sugar
Sugar |
34.3 percent target mRNA inhibition | 19282453 |
| SM0620 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Fluoro* 2-O-Methyl |
3,5,9,13,20,21
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 |
Sugar
Sugar |
67.1 percent target mRNA inhibition | 19282453 |
| SM0665 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
3,5,9,13,20,21
3,18 |
Sugar
Sugar |
28.4 percent target mRNA inhibition | 19282453 |
| SM0710 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
3,5,9,13,20,21
4,18 |
Sugar
Sugar |
25.8 percent target mRNA inhibition | 19282453 |
| SM0755 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
3,5,9,13,20,21
3,4,18 |
Sugar
Sugar |
84.4 percent target mRNA inhibition | 19282453 |
| SM0800 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
3,18 |
Sugar
Sugar |
54.3 percent target mRNA inhibition | 19282453 |
| SM0845 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
4,18 |
Sugar
Sugar |
42.7 percent target mRNA inhibition | 19282453 |
| SM0890 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
3,4,18 |
Sugar
Sugar |
86.8 percent target mRNA inhibition | 19282453 |
| SM0935 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
3,18 |
Sugar
Sugar |
42.9 percent target mRNA inhibition | 19282453 |
| SM0980 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
4,18 |
Sugar
Sugar |
47.2 percent target mRNA inhibition | 19282453 |
| SM1025 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
4-C-Hydroxymethyl Deoxyribonucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
3,5,9,13,20,21
3,4,18 |
Sugar
Sugar |
41 percent target mRNA inhibition | 19282453 |
| SM1070 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminoethyl |
3,5,9,13,20,21
20,21 |
Sugar
Sugar |
87.2 percent target mRNA inhibition | 19282453 |
| SM1115 |
GACGTAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
4-C-Hydroxymethyl Deoxyribonucleic acid
2-Aminopropyl |
3,5,9,13,20,21
1 |
Sugar
Sugar |
50.1 percent target mRNA inhibition | 19282453 |