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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 4-Thioribose are 72
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2265	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 18,19,20	0 Sugar	IC-50 = 0.088 nM for target mRNA	16509579
SM2266	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 13,14,15	0 Sugar	IC-50 = 14 nM for target mRNA	16509579
SM2267	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 12,13,14	0 Sugar	IC-50 = 0.48 nM for target mRNA	16509579
SM2268	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 16,18,19,20	0 Sugar	IC-50 = 1.1 nM for target mRNA	16509579
SM2269	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 20	0 Sugar	IC-50 = 0.24 nM for target mRNA	16509579
SM2270	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 7,8,9	0 Sugar	IC-50 = 41.5 nM for target mRNA	16509579
SM2271	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,3	0 Sugar	IC-50 = 0.45 nM for target mRNA	16509579
SM2272	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,3,5,16,18,19,20	0 Sugar	IC-50 = 5.9 nM for target mRNA	16509579
SM2274	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,18,19	0 Sugar	IC-50 = 1.2 nM for target mRNA	16509579
SM2279	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose	4,10,11,17 1,2,18,19	Sugar Sugar	IC-50 = 1.7 nM for target mRNA	16509579
SM2280	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose	1,2,18,19 1,2,18,19	Sugar Sugar	IC-50 = 0.21 nM for target mRNA	16509579
SM2282	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	2-O-(2-Methoxyethyl) 4-Thioribose	1,2,3,17,18,19 1,2,18,19	Sugar Sugar	IC-50 = 0.66 nM for target mRNA	16509579
SM4861	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 1,7,9,10,16	0 Sugar	79.5 percent target mRNA inhibition (IC-50 = 1.65 nM)	15919084
SM4862	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 2,11,12,14,18	0 Sugar	68.5 percent target mRNA inhibition (IC-50 = 2.09 nM)	15919084
SM4863	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 1,2,7,9,10,11,12,14,16,18	0 Sugar	27.5 percent target mRNA inhibition	15919084
SM4864	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	0 Sugar	16.6 percent target mRNA inhibition	15919084
SM4869	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 1,2,3,4,5,6	0 Sugar	70.9 percent target mRNA inhibition (IC-50 = 2.62 nM)	15919084
SM4870	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 14,15,16,17,18,19	0 Sugar	72.2 percent target mRNA inhibition (IC-50 = 1.98 nM)	15919084
SM4871	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 7,8,9,10,11,12,13	0 Sugar	36.5 percent target mRNA inhibition	15919084
SM4872	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 1,2,3,4,5,6,14,15,16,17,18,19	0 Sugar	22.8 percent target mRNA inhibition	15919084
SM4881	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 18,19	0 Sugar	90.2 percent target mRNA inhibition	17150641
SM4882	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	0 4-Thioribose	0 16,17,18,19	0 Sugar	85.6 percent target mRNA inhibition	17150641
SM4883	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	4-Thioribose 4-Thioribose	1,2 18,19	Sugar Sugar	91.3 percent target mRNA inhibition	17150641
SM4884	CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT	4-Thioribose 4-Thioribose	1,2,3,4 16,17,18,19	Sugar Sugar	86.1 percent target mRNA inhibition	17150641
SM4889	AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT	0 4-Thioribose	0 18,19	0 Sugar	57.2 percent target mRNA inhibition	17150641



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