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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 5,20,21 are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0030	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-O-Methyl	5,20,21 2	Sugar Sugar	43.5 percent target mRNA inhibition	19282453
SM0076	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl* 2-Aminoethyl	5,20,21 1 * 21	Sugar Sugar	56 percent target mRNA inhibition	19282453
SM0121	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl* 2-Cyanoethyl	5,20,21 1 * 18	Sugar Sugar	30.3 percent target mRNA inhibition	19282453
SM0166	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Altritol nucleic acid	5,20,21 1,2	Sugar Sugar	36.7 percent target mRNA inhibition	19282453
SM0211	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	5,20,21 20,21	Sugar Sugar	89.1 percent target mRNA inhibition	19282453
SM0256	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	5,20,21 5,8,11,14,17,20	Sugar Sugar	0.8 percent target mRNA inhibition	19282453
SM0301	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Altritol nucleic acid	5,20,21 3,6,14,18,20,21	Sugar Sugar	68.6 percent target mRNA inhibition	19282453
SM0346	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 18,19,20 * 21	Sugar Sugar	78.6 percent target mRNA inhibition	19282453
SM0391	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 2,18,19,20 * 21	Sugar Sugar	62.8 percent target mRNA inhibition	19282453
SM0436	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 3,18,19,20 * 21	Sugar Sugar	65.3 percent target mRNA inhibition	19282453
SM0481	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 2,9,18,19,20 * 21	Sugar Sugar	17.4 percent target mRNA inhibition	19282453
SM0526	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	5,20,21 18,19 * 21	Sugar Sugar	22.4 percent target mRNA inhibition	19282453
SM0571	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	5,20,21 18,19 * 21	Sugar Sugar	18.4 percent target mRNA inhibition	19282453
SM0616	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	5,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	49 percent target mRNA inhibition	19282453
SM0661	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	42.4 percent target mRNA inhibition	19282453
SM0706	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 4,18	Sugar Sugar	5.8 percent target mRNA inhibition	19282453
SM0751	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 3,4,18	Sugar Sugar	82.4 percent target mRNA inhibition	19282453
SM0796	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	72.3 percent target mRNA inhibition	19282453
SM0841	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 4,18	Sugar Sugar	25.2 percent target mRNA inhibition	19282453
SM0886	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 3,4,18	Sugar Sugar	87.1 percent target mRNA inhibition	19282453
SM0931	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	66.6 percent target mRNA inhibition	19282453
SM0976	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,20,21 4,18	Sugar Sugar	28.1 percent target mRNA inhibition	19282453
SM1021	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,20,21 3,4,18	Sugar Sugar	72.8 percent target mRNA inhibition	19282453
SM1066	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-Aminoethyl	5,20,21 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1111	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-Aminopropyl	5,20,21 1	Sugar Sugar	30 percent target mRNA inhibition	19282453



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