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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 5,21 are 48
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0042	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-O-Methyl	5,21 2	Sugar Sugar	56 percent target mRNA inhibition	19282453
SM0088	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Aminoethyl	5,21 1 * 21	Sugar Sugar	55.7 percent target mRNA inhibition	19282453
SM0133	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Cyanoethyl	5,21 1 * 18	Sugar Sugar	21.2 percent target mRNA inhibition	19282453
SM0178	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid Altritol nucleic acid	5,21 1,2	Sugar Sugar	28.9 percent target mRNA inhibition	19282453
SM0223	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 20,21	Sugar Sugar	88.2 percent target mRNA inhibition	19282453
SM0268	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 5,8,11,14,17,20	Sugar Sugar	21.6 percent target mRNA inhibition	19282453
SM0313	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 3,6,14,18,20,21	Sugar Sugar	77.2 percent target mRNA inhibition	19282453
SM0358	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 18,19,20 * 21	Sugar Sugar	78.3 percent target mRNA inhibition	19282453
SM0403	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 2,18,19,20 * 21	Sugar Sugar	58.6 percent target mRNA inhibition	19282453
SM0448	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 3,18,19,20 * 21	Sugar Sugar	66.6 percent target mRNA inhibition	19282453
SM0493	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 2,9,18,19,20 * 21	Sugar Sugar	1.8 percent target mRNA inhibition	19282453
SM0538	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	5,21 18,19 * 21	Sugar Sugar	14.1 percent target mRNA inhibition	19282453
SM0583	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	5,21 18,19 * 21	Sugar Sugar	4.5 percent target mRNA inhibition	19282453
SM0628	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Fluoro* 2-O-Methyl	5,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	66.6 percent target mRNA inhibition	19282453
SM0673	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,21 3,18	Sugar Sugar	42.7 percent target mRNA inhibition	19282453
SM0718	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,21 4,18	Sugar Sugar	40.8 percent target mRNA inhibition	19282453
SM0763	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,21 3,4,18	Sugar Sugar	86.7 percent target mRNA inhibition	19282453
SM0808	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,21 3,18	Sugar Sugar	76.4 percent target mRNA inhibition	19282453
SM0853	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,21 4,18	Sugar Sugar	56.6 percent target mRNA inhibition	19282453
SM0898	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,21 3,4,18	Sugar Sugar	87.9 percent target mRNA inhibition	19282453
SM0943	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,21 3,18	Sugar Sugar	71 percent target mRNA inhibition	19282453
SM0988	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,21 4,18	Sugar Sugar	64.4 percent target mRNA inhibition	19282453
SM1033	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,21 3,4,18	Sugar Sugar	66.7 percent target mRNA inhibition	19282453
SM1078	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-Aminoethyl	5,21 20,21	Sugar Sugar	89.2 percent target mRNA inhibition	19282453
SM1123	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-Aminopropyl	5,21 1	Sugar Sugar	38 percent target mRNA inhibition	19282453



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