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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for 5,8,14,17,22 are 48
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0004
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    5,8,14,17,22
    2
    Sugar
    Sugar
    35.4 percent target mRNA inhibition
    19282453
    SM0050
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,8,14,17,22
    1 * 21
    Sugar
    Sugar
    22 percent target mRNA inhibition
    19282453
    SM0095
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,8,14,17,22
    1 * 18
    Sugar
    Sugar
    24.8 percent target mRNA inhibition
    19282453
    SM0140
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    1,2
    Sugar
    Sugar
    40.4 percent target mRNA inhibition
    19282453
    SM0185
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    20,21
    Sugar
    Sugar
    59.1 percent target mRNA inhibition
    19282453
    SM0230
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0275
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    3,6,14,18,20,21
    Sugar
    Sugar
    1.4 percent target mRNA inhibition
    19282453
    SM0320
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,8,14,17,22
    18,19,20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0365
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,8,14,17,22
    2,18,19,20 * 21
    Sugar
    Sugar
    6.4 percent target mRNA inhibition
    19282453
    SM0410
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,8,14,17,22
    3,18,19,20 * 21
    Sugar
    Sugar
    5.1 percent target mRNA inhibition
    19282453
    SM0455
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,8,14,17,22
    2,9,18,19,20 * 21
    Sugar
    Sugar
    9.5 percent target mRNA inhibition
    19282453
    SM0500
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    2-Aminoethoxymethyl* 2-Deoxy
    5,8,14,17,22
    18,19 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0545
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    2-Aminopropoxymethyl* 2-Deoxy
    5,8,14,17,22
    18,19 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0590
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-Fluoro* 2-O-Methyl
    5,8,14,17,22
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0635
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,8,14,17,22
    3,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0680
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,8,14,17,22
    4,18
    Sugar
    Sugar
    9 percent target mRNA inhibition
    19282453
    SM0725
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,8,14,17,22
    3,4,18
    Sugar
    Sugar
    0.5 percent target mRNA inhibition
    19282453
    SM0770
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,8,14,17,22
    3,18
    Sugar
    Sugar
    24.3 percent target mRNA inhibition
    19282453
    SM0815
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,8,14,17,22
    4,18
    Sugar
    Sugar
    0.2 percent target mRNA inhibition
    19282453
    SM0860
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,8,14,17,22
    3,4,18
    Sugar
    Sugar
    10.3 percent target mRNA inhibition
    19282453
    SM0905
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,8,14,17,22
    3,18
    Sugar
    Sugar
    8.8 percent target mRNA inhibition
    19282453
    SM0950
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,8,14,17,22
    4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0995
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,8,14,17,22
    3,4,18
    Sugar
    Sugar
    11 percent target mRNA inhibition
    19282453
    SM1040
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminoethyl
    5,8,14,17,22
    20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    19282453
    SM1085
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminopropyl
    5,8,14,17,22
    1
    Sugar
    Sugar
    38.6 percent target mRNA inhibition
    19282453