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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 8,9,12,14,15,16,17,18 are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2257
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19
    Sugar
    Sugar
    37 percent target mRNA inhibition
    16598842
    SM2260
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    53 percent target mRNA inhibition
    16598842
    SM2261
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-O-Methyl
    8,9,12,14,15,16,17,18
    1,7,13,14,15,16,17,18,19
    Sugar
    Sugar
    74 percent target mRNA inhibition
    16598842
    SM2262
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    2-O-Methyl
    2-Fluoro* Inverted DeoxyThymidine
    8,9,12,14,15,16,17,18
    1,7,9,10,13,14,15,16,17,18,19 *21
    Sugar
    Sugar
    77 percent target mRNA inhibition
    16598842