Unmodified siRNA used as control in testing chemically modified siRNA as reported in this database

SMId

Sense sequence

Antisense sequence

Biological activity

SiRNA Concentration used

Reference

SM0046

NA (siEGFP mismatch control)

NA (siEGFP mismatch control)

0 percent target mRNA inhibition

10 nM

19282453

SM1442

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

85.5 percent target mRNA inhibition

10 nM

19282453

SM2172

AUCUGAAGAAGGAGAAAAATT

UUUUUCUCCUUCUUCAGAUTT

88 percent target mRNA inhibition

0.3 nM

19042976

SM2181

AUCUGAAGAAGGAGAAAAATT

UCCUUUCUUUCUUUCGAAUTT

2 percent target mRNA inhibition

0.3 nM

19042976

SM2184

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

NA

400ug/kg; 4mg/kg; 10mg/kg

19401674

SM2190

CGUACGCGGAAUACUUCGAUU

UCGAAGUAUUCCGCGUACGUG

4.23 percent target mRNA inhibition

50 nM

18575806

SM2191

GCAGCACGACUUCUUCAAGUU

CUUGAAGAAGUCGUGCUGCUU

77.3 percent target mRNA inhibition

50 nM

18575806

SM2200

UAGUUCUGUGGGGCUGUUUUU

AAACAGCCCCACAGAACUAUU

NA

50 nM

18575806

SM2203

UUCUUCGAACGUGUCACGUTT

ACGUGACACGUUCGAAGAATT

26 percent target mRNA inhibition

2 nM

17894530

SM2204

CUGGAGCAAGUUGCAAAGCAUUGGAAU

AUUCCAAUGCUUUGCAACUUGCUCCAG

4 percent target mRNA inhibition

2 nM

17894530

SM2205

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

88 percent target mRNA inhibition

2 nM

17894530

SM2206

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

48 percent target mRNA inhibition

50 nM

17894530

SM2208

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

87 percent target mRNA inhibition

2 nM

17894530

SM2217

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

83 percent target mRNA inhibition

50 nM

17894530

SM2235

GGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

83 percent target mRNA inhibition

0.5 nM

17894530

SM2239

AAGGAGAUCAACAUUUUCATT

UGAAAAUGUUGAUCUCCUUTT

81 percent target mRNA inhibition

2 nM

16598842

SM2264

AAGUAAGGACCAGAGACAAA

UUUGUCUCUGGUCCUUACUU

IC-50 = 0.95 nM for target mRNA

0.95 nM

16509579

SM2273

AAGUAAGGACCAGAGACAA

UUGUCUCUGGUCCUUACUU

IC-50 = 0.4 nM for target mRNA

0.4 nM

16509579

SM2287

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

66 percent target mRNA inhibition

2 nM

15715458

SM2288

AAGUAAGGACCAGAGACAA

UUGUCUCUGGUCCUUACUU

72 percent target mRNA inhibition (IC-50 = 0.26 nM)

2 nM

15715458

SM2289

AAGCAAGGAGAAGCGAUAA

UUAUCGCUUCUCGUUGCUU

0 percent target mRNA inhibition

2 nM

15715458

SM2290

GGGUAAAUACAUUCUUCAUTT

AUGAAGAAUGUAUUUACCCTT

62 percent target mRNA inhibition

2 nM

15715458

SM2291

GGGUAAAUACAUUCUUCAU

AUGAAGAAUGUAUUUACCC

64 percent target mRNA inhibition (IC-50 = 0.81 nM)

2 nM

15715458

SM2292

GGGAAAGUAUCUUGUUUAU

AUAAACAAGAUACUUUCCC

10 percent target mRNA inhibition

2 nM

15715458

SM2314

ACAUGAAGCAGCACGACUUTT

AAGUCGUGCUGCUUCAUGUTT

90 percent target mRNA inhibition

20 nM

17585051

SM2315

AUGAAGCAGCACGACUUTT

AAGUCGUGCUGCUUCAUTT

75 percent target mRNA inhibition

20 nM

17585051

SM2316

GAAGCAGCACGACUUTT

AAGUCGUGCUGCUUCTT

5 percent target mRNA inhibition

20 nM

17585051

SM2320

AGCUUUGUGGAGAUGGUGGTT

CCACCAUCUCCACAAAGCUTT

70 percent target mRNA inhibition

5 nM

17585051

SM2323

AUACAGGCAGCAGUAACUUUTT

AAAGUUACUGCUGCCUGUAUTT

62 percent target mRNA inhibition

1 nM

17585051

SM2343

AUCUGAAGAAGGAGAAAAATT

UUUUUCUCCUUCUUCAGAUTT

91 percent target mRNA inhibition

0.8 nM

23764303

SM2348

CGUGACCGCACACCCAAUATT

UAUUGGGUGUGCGGUCACGGT

26 percent target mRNA inhibition

10 nM

23743442

SM2349

ACCUUGAGGCAUACUUCAATT

UUGAAGUAUGCCUCAAGGUCG

90 percent target mRNA inhibition

10 nM

23743442

SM2370

CUUCUUCGUCGAGACCAUGTT

CAUGGUCUCGACGAAGAAGTT

35 percent target mRNA inhibition

0.1 nM

23743279

SM2377

CUUCUUCGUCGAGACCAUGTT

CAUGGUCUCGACGAAGAAGTT

64 percent target mRNA inhibition

1 nM

23743279

SM2384

CUUCUUCGUCGAGACCAUGTT

CAUGGUCUCGACGAAGAAGTT

82 percent target mRNA inhibition

10 nM

23743279

SM2410

AAUCAGACAAGUUCUUCAUTT

AUGAAGAACUUGUCUGAUUTT

96 percent target mRNA inhibition

1 nM

23682800

SM2416

AAUCAGACAAGUUCUUCAUTT

AUGAAGAACUUGUCUGAUUTT

83 percent target mRNA inhibition

0.1 nM

23682800

SM2422

GGAUAUUGUCAGUCUUUAGGUU

CCUAAAGACUGACAAUAUCCUU

NA

1 nM

23449220

SM2435

GGAUAUUGUCAGUCUUUAGGUU

CCUAAAGACUGACAAUAUCCUU

62 percent target mRNA inhibition

1 nM

23449220

SM2441

GGAUAUUGUCAGUCUUUAGGUU

CCUAAAGACUGACAAUAUCCUU

82 percent target mRNA inhibition

1 nM

23449220

SM2447

AUCUGAAGAAGGAGAAAAATT

UUUUUCUCCUUCUUCAGAUTT

IC-50 = 0.025 nM for target mRNA

0.025 nM

23362010

SM2454

UAUCGAAAGAAAGAAAGGATT

UCCUUUCUUUCUUUCGAUATT

NA

NA

23362010

SM2478

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

83 percent target mRNA inhibition

1 nM

22982308

SM2486

CAGCAAACCACGAUCAAUATT

UAUUGAUCGUGGUUUGCUGTT

71 percent target mRNA inhibition

50 nM

22889374

SM2489

CAGAGCAAUUGUUUACCUATT

UAGGUAAACAAUUGCUCUGTT

73 percent target mRNA inhibition

50 nM

22889374

SM2492

GGAUUGACCUCUCAUAUAATT

UUAUAUGAGAGGUCAAUCCTT

0 percent target mRNA inhibition

50 nM

22889374

SM2497

CGUUAGCAGAAACAAAAGGAG

CUCCUUUUGUUUCUGCUAACG

High target mRNA inhibition efficacy

1 to 40 nM

12771196

SM2498

CGUGAGCACAAAGAAAAUGAG

CUCAUUUUCUUUGUGCUCACG

Low mRNA target inhibition efficacy

1 to 40 nM

12771196

SM2503

UGGAAUGAACCACUGGAAUUU

AAAUUCCAGUGGUUCAUUCCA

High target mRNA inhibition efficacy

1 to 40 nM

12771196

SM2505

CGAGGGGAGUACAUCAAGAUU

UCUUGAUGUACUCCCCUCGUU

High target mRNA inhibition efficacy

1 to 40 nM

12771196

SM2506

CGAGGGGAGUACAUCAAGACC

UCUUGAUGUACUCCCCUCGUU

High target mRNA inhibition efficacy

1 to 40 nM

12771196

SM2509

GAGGGGAGUACAUCAAGAC

CUUGAUGUACUCCCCUCUG

Low mRNA target inhibition efficacy

1 to 40 nM

12771196

SM2533

UCUUGAUGUACUCCCCUCGTT

CGAGGGGAGUACAUCAAGATT

NA

1 to 40 nM

12771196

SM2539

AAUUCCAGUGGUUCAUUCC

GGAAUGAACCACUGGAAUU

NA

1 to 40 nM

12771196

SM2544

UGGCCAAUGCCAAGGAGAUUU

AUCUCCUUGGCAUUGGCCAUU

16 percent target mRNA inhibition

0.1 nM

17511001

SM2553

UGGCCAAUGCCAAGGAGAUUU

AUCUCCUUGGCAUUGGCCAUU

49 percent target mRNA inhibition

1 nM

17511001

SM2562

UGGCCAAUGCCAAGGAGAUUU

AUCUCCUUGGCAUUGGCCAUU

60 percent target mRNA inhibition

5 nM

17511001

SM2571

UGGCCAAUGCCAAGGAGAUUU

AUCUCCUUGGCAUUGGCCAUU

90 percent target mRNA inhibition

20 nM

17511001

SM2580

GCUGCGCUAUGGCGAAGACGG

GUCUUCGCCAUAGCGCAGCTG

High target mRNA inhibition efficacy

0.15 mg/kg/ twice weekly

17363479

SM2581

GCUGCGCUACUGCGAAGACGG

GUCUUCGCAGUAGCGCAGCTG

Low mRNA target inhibition efficacy

0.15 mg/kg/ twice weekly

17363479

SM2582

GCUGACCCUGAAGUUCAUCTT

GAUGAACUUCAGGGUCAGCTT

90 percent target mRNA inhibition

0.25 mg/kg/d

17363479

SM2585

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

IC-50 = 0.21 nM for target mRNA

0.4 to 30 nM

17163665

SM2592

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

IC-50 (Less than than 30 nM) for target mRNA

0.4 to 30 nM

17163665

SM2593

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

IC-50 (Less than than 30 nM) for target mRNA

0.4 to 30 nM

17163665

SM2594

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

IC-50 = 0.92 nM for target mRNA

0.4 to 30 nM

17163665

SM2595

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAdTT

82 percent target mRNA inhibition

10 nM

17881374

SM2599

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAATT

35 percent target mRNA inhibition

10 nM

17881374

SM2600

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAATT

35 percent target mRNA inhibition

10 nM

17881374

SM2601

GCGGAUCAAACCUCACCAATT

UUGGUGAGGUUUGAUCCGCTT

93 percent target mRNA inhibition

17 nM

17881374

SM2606

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

71 percent target mRNA inhibition

10 nM

17904849

SM2613

CGUACGCGGAAUACUUCGAUU

UCGAAGUAUUCCGCGUACGUU

69 percent target mRNA inhibition

25 nM

18094121

SM2614

CGUACGCGGAAUACUUCGAUU

TCGAAGUAUUCCGCGUACGUU

75 percent target mRNA inhibition

25 nM

18094121

SM2616

TGUACGCGGAAUACUUCGAUU

UCGAAGUAUUCCGCGUACGUU

65 percent target mRNA inhibition

25 nM

18094121

SM2618

UUAGUCGAAUGCAAGACAAUT

UUGUCUUGCAUUCGACUAAUT

90 percent target mRNA inhibition

25 nM

18094121

SM2622

UUAAGAUCUGUUAUCCGCAUT

UGCGGAUAACAGAUCUUAAUT

89 percent target mRNA inhibition

25 nM

18094121

SM2626

UUAAGAUCUGUUAUCCGCAUT

UGCGGAUAACAGAUCUUAAUT

70 percent target mRNA inhibition

25 nM

18094121

SM2627

UUAAGAUCUGUUAUCCGCAUT

AGCGGAUAACAGAUCUUAAUT

69 percent target mRNA inhibition

25 nM

18094121

SM2628

UUAAGAUCUGUUAUCCGCAUT

UCCGGAUAACAGAUCUUAAUT

76 percent target mRNA inhibition

25 nM

18094121

SM2629

UUAAGAUCUGUUAUCCGCAUT

UGGGGAUAACAGAUCUUAAUT

65 percent target mRNA inhibition

25 nM

18094121

SM2630

UUAAGAUCUGUUAUCCGCAUT

UGCCGAUAACAGAUCUUAAUT

60 percent target mRNA inhibition

25 nM

18094121

SM2631

UUAAGAUCUGUUAUCCGCAUT

UGCGCAUAACAGAUCUUAAUT

61 percent target mRNA inhibition

25 nM

18094121

SM2635

CGAUGUGUCUAUUGAAGAUUC

AUCUUCAAUAGACACAUCGGC

3 percent target mRNA inhibition

0.002 nM

18367449

SM2637

CGAUGUGUCUAUUGAAGAUUC

AUCUUCAAUAGACACAUCGGC

14 percent target mRNA inhibition

0.02 nM

18367449

SM2639

CGAUGUGUCUAUUGAAGAUUC

AUCUUCAAUAGACACAUCGGC

55 percent target mRNA inhibition

0.2 nM

18367449

SM2641

CGAUGUGUCUAUUGAAGAUUC

AUCUUCAAUAGACACAUCGGC

68 percent target mRNA inhibition

2 nM

18367449

SM2644

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

88 percent target mRNA inhibition

25 nM

19233658

SM2658

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

83 percent target mRNA inhibition

100 nM

19325750

SM2662

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

80 percent target mRNA inhibition

10 nM

19325750

SM2666

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

75 percent target mRNA inhibition

1 nM

19325750

SM2670

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

64 percent target mRNA inhibition

0.1 nM

19325750

SM2674

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

NA

10 nM

20005874

SM2675

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

NA

10 nM

20005874

SM2676

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

0 percent target mRNA inhibition

10 nM

20005874

SM2683

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

2.75 (log-10 CVB-3 titre pfu/ml)

10 nM

20005874

SM2684

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

2.55 (log-10 CVB-3 titre pfu/ml)

10 nM

20005874

SM2685

CUAAGGACCUAACAAAGUUUUU

AACUUUGUUAGGUCCUUAGUU

2.9 (log-10 CVB-3 titre pfu/ml)

10 nM

20005874

SM2686

CUAAGGACCUAACAAAGUUUU

AACUUUGUUAGGUCCUUAGUU

4 (log-10 CVB-3 titre pfu/ml)

10 nM

20005874

SM2687

UUCUCCGAACGUGUCACGUUUU

ACGUGACACGUUCGGAGAAUUU

NA

10 nM

20005874

SM2706

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

78 percent target mRNA inhibition

0.032 nM

20485810

SM2713

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

74 percent target mRNA inhibition

0.032 nM

20485810

SM2720

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

75 percent target mRNA inhibition

0.32 nM

20485810

SM2727

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

72 percent target mRNA inhibition

0.32 nM

20485810

SM2734

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

72 percent target mRNA inhibition

0.32 nM

20485810

SM2741

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

67 percent target mRNA inhibition

0.32 nM

20485810

SM2748

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

77 percent target mRNA inhibition

0.32 nM

20485810

SM2755

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

69 percent target mRNA inhibition

0.32 nM

20485810

SM2762

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

66 percent target mRNA inhibition

0.32 nM

20485810

SM2769

UCGAAGUAUUCCGCGUACGTT

CGUACGCGGAAUACUUCGATT

70 percent target mRNA inhibition

0.32 nM

20485810

SM2776

CUUACGCUGAGUACUUCGATT

TCGAAGUACUCAGCGUAAGTT

NA

0.002 to 8.0 nM

20610434

SM2821

CUUACGCUGAGUACUUCGATT

TCGAAGUACUCAGCGUAAGTT

IC-50 = 0.144 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2827

CUUACGCUGAGUACUUCGAAA

UCGAAGUACUCAGCGUAAGUG

IC-50 = 0.144 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2837

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.179 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2838

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.092 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2839

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.076 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2840

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.066 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2841

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.052 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2842

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.021 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2843

AAGUAAGGACCAGAGACAATT

UUGUCUCUGGUCCUUACUUTT

IC-50 = 0.053 nM for target mRNA

0.002 to 8.0 nM

20610434

SM2848

CAAGUGUCAUCACACUGAATT

UUCAGUGUGAUGACACUUGTT

61 percent target mRNA inhibition

10 nM

21942264

SM2868

CAAGUGUCAUCACACUGAATT

UUCAGUGUGAUGACACUUGTT

81 percent target mRNA inhibition

10 nM

21942264

SM2888

CAAGUGUCAUCACACUGAATT

UUCAGUGUGAUGACACUUGTT

81 percent target mRNA inhibition

10 nM

21942264

SM2908

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

High target mRNA inhibition efficacy

1 nM

21687525

SM2915

GACUUAGACUGACACAAGUUC

CUUGUGUCAGUCUAAGUCGC

High target mRNA inhibition efficacy

1 nM

21687525

SM2916

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

High target mRNA inhibition efficacy

5 nM

21687525

SM2923

GACUUAGACUGACACAAGUUC

CUUGUGUCAGUCUAAGUCGC

High target mRNA inhibition efficacy

5 nM

21687525

SM2924

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

High target mRNA inhibition efficacy

25 nM

21687525

SM2931

GACUUAGACUGACACAAGUUC

CUUGUGUCAGUCUAAGUCGC

High target mRNA inhibition efficacy

25 nM

21687525

SM2932

GACGUAAACGGCCACAAGUUC

ACUUGUGGCCGUUUACGUCGC

High target mRNA inhibition efficacy

0.25 mg/kg/day

21687525

SM2939

GACUUAGACUGACACAAGUUC

CUUGUGUCAGUCUAAGUCGC

High target mRNA inhibition efficacy

0.25 mg/kg/day

21687525

SM2940

AAGCUGACCCUGAAGUUCAUCUGCACC

GGUGCAGAUGAACUUCAGGGUCAGCUU

82 percent target mRNA inhibition

1.56 nM

21739319

SM2946

AAGCUGACCCUGAAGUUCAUCUGCACC

GGUGCAGAUGAACUUCAGGGUCAGCUU

91 percent target mRNA inhibition

1.56 nM

21739319

SM2952

GUAUGACCGACUACGCGUATT

UUCAGUGUGAUGACACUUGTT

95 percent target mRNA inhibition (IC-50 = 0.123 nM)

10 nM

19917641

SM2976

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

93 percent target mRNA inhibition

50 nM

12923253

SM3002

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

35 percent target mRNA inhibition

50 nM

12923253

SM3003

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

77 percent target mRNA inhibition

50 nM

12923253

SM3008

GACGUAAACGGCCACAAGUUCU

ACUUGUGGCCGUUUACGUCGCU

89 percent target mRNA inhibition

10 nM

22287630

SM3016

GUUCACCUUGAUGCCGUUCUU

GAACGGCAUCAAGGUGAACUU

78 percent target mRNA inhibition

25 nM

15545637

SM3031

GUUCACCUUGAUGCCGUUCUU

GAACGGAACUACGGUGAACUU

0 percent target mRNA inhibition

25 nM

15545637

SM3032

GUUCACCUUGAUGCCGUUCUU

GAACGGAACUACGGUGAACUU

0 percent target mRNA inhibition

25 nM

15545637

SM3033

GUUCACCUUGAUGCCGUUCUU

GCACGACUUCUUCAAGUCCUU

65 percent target mRNA inhibition

25 nM

15545637

SM3036

GUUCACCUUGAUGCCGUUCUU

GCACGCUUCUUCAAAGUCCUU

0 percent target mRNA inhibition

25 nM

15545637

SM3037

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

95 percent target mRNA inhibition

13 nM

15653644

SM3038

AUCUGAAGAAGGAGAAAAATT

UUUUUCUCCUUCUUCAGAUTT

90 percent target mRNA inhibition

13 nM

15653644

SM3039

UGAGAGAAAGCACAGAAAATT

UUUUCUGUGCUUUCUCUCATT

73 percent target mRNA inhibition

13 nM

15653644

SM3040

AAACAUGCAGAAAAYGCUGTT

CAGCAUUUUCUGCAUGUUUTT

43 percent target mRNA inhibition

13 nM

15653644

SM3041

UCCAGAACAAAACCAAACGGTT

CCGUUUGGUUUGUUCUGGATT

28 percent target mRNA inhibition

13 nM

15653644

SM3042

GGACGAGGAAGGCAAUUUATT

UAAAUUGCCUUCCUCAUCCTT

48 percent target mRNA inhibition

13 nM

15653644

SM3043

CUGGUACGAUUUCGGUGAUTT

AGCACCGAAAUCGUACCAGTT

0 percent target mRNA inhibition

13 nM

15653644

SM3044

ACUGUCAAACCCGGUAAUUTT

AAUUACCGGGUUUGACAGUTT

15 percent target mRNA inhibition

13 nM

15653644

SM3089

GCUUGAAGUCUUUAAUUAATT

UUAAUUAAAGACUUCAAGCGG

IC-50 = 0.16 nM for target mRNA

0.16 nM

17284457

SM3090

GCUUGAAGUCUUUAAUUAATT

UUAAUUAAAGACUUCAAGCGG

IC-50 = 0.04 nM for target mRNA

1.04 nM

17284457

SM3099

GCUUGAAGUCUUUAAUUAATT

UUAAUUAAAGACUUCAAGCGG

IC-50 = 0.16 nM for target mRNA

0.16 nM

17284457

SM3100

GCUUGAAGUCUUUAAUUAAGG

UUAAUUAAAGACUUCAAGCGG

IC-50 = 0.87 nM for target mRNA

0.87 nM

17284457

SM3110

AUCUGAAGAAGGAGAAAAATT

UUUUUCUCCUUCUUCAGAUTT

95 percent target mRNA inhibition

2.1 ng

18624291

SM3115

ACCUGACGUUGUACAAAUUTT

AAUUUGUACAACGUCAGGUTT

85 percent target mRNA inhibition

2.1 ng

18624291

SM3129

CUUCCUCUCUUUCUCUCCCUUGUGA

UCACAAGGGAGAGAAAGAGAGGAAGGA

0 percent target mRNA inhibition

10 nM

18637735

SM3130

GCACCAGAGCCAAUGGAACUUGATG

CAUCAAGUUCCAUUGGCUCUGGUGCUU

93 percent target mRNA inhibition

10 nM

18637735

SM3147

CUUCCUCUCUUUCUCUCCCUUGUGA

UCACAAGGGAGAGAAAGAGAGGAAGGA

0 percent target mRNA inhibition

1 nM

18637735

SM3148

GCACCAGAGCCAAUGGAACUUGATG

CAUCAAGUUCCAUUGGCUCUGGUGCUU

95 percent target mRNA inhibition

1 nM

18637735

SM3165

CUUCCUCUCUUUCUCUCCCUUGUGA

UCACAAGGGAGAGAAAGAGAGGAAGGA

0 percent target mRNA inhibition

0.1 nM

18637735

SM3166

GCACCAGAGCCAAUGGAACUUGATG

CAUCAAGUUCCAUUGGCUCUGGUGCUU

87 percent target mRNA inhibition

0.1 nM

18637735

SM3183

GCCAGACUUUGUUGGAUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

0 percent target mRNA inhibition

0.1 nM

18637735

SM3184

ACCCUGAAGUUCAUCUGCACCACCG

CGGUGGUGCAGAUGAACUUCAGGGUCA

34 percent target mRNA inhibition

0.1 nM

18637735

SM3189

GCCAGACUUUGUUGGAUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

0 percent target mRNA inhibition

1 nM

18637735

SM3190

ACCCUGAAGUUCAUCUGCACCACCG

CGGUGGUGCAGAUGAACUUCAGGGUCA

96 percent target mRNA inhibition

1 nM

18637735

SM3195

GCCAGACUUUGUUGGAUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

0 percent target mRNA inhibition

10 nM

18637735

SM3196

ACCCUGAAGUUCAUCUGCACCACCG

CGGUGGUGCAGAUGAACUUCAGGGUCA

98 percent target mRNA inhibition

10 nM

18637735

SM3201

CUUCCUCUCUUUCUCUCCCUUGUGA

UCACAAGGGAGAGAAAGAGAGGAAGGA

0 percent target mRNA inhibition

10 nM

18637735

SM3202

GCCAGACUUUGUUGGAUUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

81 percent target mRNA inhibition

0.1 nM

18637735

SM3205

GCCAGACUUUGUUGGAUUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

93 percent target mRNA inhibition

1 nM

18637735

SM3208

GCCAGACUUUGUUGGAUUUUGAAATT

AAUUUCAAAUCCAACAAAGUCUGGCUU

96 percent target mRNA inhibition

10 nM

18637735

SM3211

GCCAGUAAUUCAGCAGUUUGAACAA

UUGUUCAAACUGCUGAAUUACUGGCUG

43 percent target mRNA inhibition

0.01 nM

18637735

SM3213

CACCAAUGAAUUCUCGAUUGAUGTG

CACAUCAAUCGAGAAUUCAUUGGUGUU

NA

NA

18637735

SM3215

GCAUUCCAGAGAAAGCGUUUAAUTT

AAAUUAAACGCUUUCUCUGGAAUGCCU

54 percent target mRNA inhibition

0.01 nM

18637735

SM3217

GCCAGUAAUUCAGCAGUUUGAACAA

UUGUUCAAACUGCUGAAUUACUGGCUG

78 percent target mRNA inhibition

0.05 nM

18637735

SM3219

CACCAAUGAAUUCUCGAUUGAUGTG

CACAUCAAUCGAGAAUUCAUUGGUGUU

NA

NA

18637735

SM3221

GCAUUCCAGAGAAAGCGUUUAAUTT

AAAUUAAACGCUUUCUCUGGAAUGCCU

83 percent target mRNA inhibition

0.05 nM

18637735

SM3223

GCCAGUAAUUCAGCAGUUUGAACAA

UUGUUCAAACUGCUGAAUUACUGGCUG

89 percent target mRNA inhibition

0.0250 nM

18637735

SM3225

CACCAAUGAAUUCUCGAUUGAUGTG

CACAUCAAUCGAGAAUUCAUUGGUGUU

NA

NA

18637735

SM3227

GCAUUCCAGAGAAAGCGUUUAAUTT

AAAUUAAACGCUUUCUCUGGAAUGCCU

87 percent target mRNA inhibition

0.025 nM

18637735

SM3229

GUGGGAGCGCGUGAUGAACTT

GUUCAUCACGCGCUCCCACTT

0 percent target mRNA inhibition

50 nM

18776474

SM3230

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

80 percent target mRNA inhibition

50 nM

18776474

SM3234

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

77 percent target mRNA inhibition

20 nM

21687522

SM3235

GUGGGAGCGCGUGAUGAACTT

GUUCAUCACGCGCUCCCACTT

0 percent target mRNA inhibition

20 nM

21687522

SM3248

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

52 percent target mRNA inhibition

5 nM

21687522

SM3249

GUGGGAGCGCGUGAUGAACTT

GUUCAUCACGCGCUCCCACTT

0 percent target mRNA inhibition

5 nM

21687522

SM3262

GCAGCACGACUUCUUCAAGTT

CUUGAAGAAGUCGUGCUGCTT

26 percent target mRNA inhibition

2 nM

21687522

SM3263

GUGGGAGCGCGUGAUGAACTT

GUUCAUCACGCGCUCCCACTT

0 percent target mRNA inhibition

2 nM

21687522

SM3276

GUAUUGACAGCUAUUCGAATT

UUCGAAUAGCUGUCAAUACTT

36 percent target mRNA inhibition

50 nM

17264131

SM3307

GCACGAAUCCUAAACCUCAUU

UGAGGUUUAGGAUUCGUGCUU

89 percent target mRNA inhibition

20 nM

19948766

SM3308

GCACGAAUCCUAAACCUCACAAUAUGAGGUUUAGGAUUCGUGCUU

0

53 percent target mRNA inhibition

20 nM

19948766

SM3309

UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA

0

90 percent target mRNA inhibition (IC-50 = 0.0035 nM)

20 nM

19948766

SM3310

UUUUUCUUUGAGGUUUAGGUUCCUAAACCUCAAAGAAAAAUU

0

90 percent target mRNA inhibition

20 nM

19948766

SM3311

UGAGGUUUAGGAUUCGUGUUCACGAAUCCUAAACCUCA

0

NA

20 nM

19948766

SM3312

AUUCGUGCUCAUGGUGCACUUGUGCACCAUGAGCACGAAUUU

0

74 percent target mRNA inhibition

20 nM

19948766

SM3313

ACGAAUCCUAAACCUCA

UGAGGUUUAGGAUUCGUGC

NA

20 nM

19948766

SM3314

UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCAUU

0

NA

20 nM

19948766

SM3321

UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA

0

95 percent target mRNA inhibition

20 nM

19948766

SM3337

ACGAAUCCUAAACCUCA

UGAGGUUUAGGAUUCGUGC

95 percent target mRNA inhibition

20 nM

19948766

SM3350

AGACGAGCUGAGCGAGAAGTT

TTUCUGCUCGACUCGCUCUUC

NA

200 nM

12834349

SM3369

CUUACGCUGAGUACUUCGAUU

UUUGAAUGCGACUCAUGAAGCU

NA

20 nM

18066804

SM3372

GUGGUAUUGUUCCUCCUAATT

UUAGGAGGAACAAUACCACTT

IC-50 = 1.5 nM for target mRNA

0.6 to 45 nM

16343994

SM3375

GUGAUCAGACUCAAUACGAAU

AUUCGUAUUGAGUCUGAUCACAC

IC-50 = 1.5 nM for target mRNA

0.6 to 45 nM

16343994

SM3377

GUCAUCACACUGAAUACCAAU

AUUGGUAUUCAGUGUGAUGACAC

IC-50 = 1.5 nM for target mRNA

0.6 to 45 nM

16343994

SM3381

UUGAUGUGUUUAGUCGCUAUU

UAGCGACUAAACACAUCAAUU

IC-50 = 1.5 nM for target mRNA

0.6 to 45 nM

16343994

SM3383

TTAUCUCCAUGCACGACUCCG

UAGAGGUACGUGCUGAGGCTT

34 percent target mRNA inhibition

25 and 50 nM

17979170

SM3388

GGACCACCGCAUCUCUACATT

GGACCACCGCAUCUCUACATT

NA

10 nM

20704260

SM3405

CGAUGUGUCUAUUGAAGAUUC

CGGCUACACAGAUAACUUCUA

NA

20 nM

18367449

SM3440

AGCGCUUAAAGGGCGAGAAGAUU

UCUUCUCGCCCUUUAAGCGCUUU

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3458

AGCGCUUAAAGGGCGAGAAGAUU

UCUUCUCGCCCUUUAAGCGCUUU

85 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3465

AACCCACCACAGCUAGAACUU

AAGUUCUAGCUGUGGUGGGUU

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3483

AACCCACCACAGCUAGAACUU

AAGUUCUAGCUGUGGUGGGUU

78 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3503

AGAAGGACUACUAACCUCCTT

GGAGGUUAGUAGUCCUUCUTT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3507

GGACUACUAACCUCCAGUUTT

AACUGGAGGUUAGUAGUCCTT

69 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3511

GAAACUGGUACUUUCCCCCTT

GGGGGAAAGUACCAGUUUCTT

69 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3515

UUUCCCCCAGGUAACGAUUTT

AAUCGUUACCUGGGGGAAATT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3519

CCCCAGGUAACGAUUUUCUTT

AGAAAAUCGUUACCUGGGGTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3523

GGGAAACUGAAAGGCUAUGTT

CAUAGCCUUUCAGUUUCCCTT

57 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3527

GCGAGCAGAGAAUCUACCUTT

AGGUAGAUUCUCUGCUCGCTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3531

GCAGAGAAUCUACCUUUCCTT

GGAAAGGUAGAUUCUCUGCTT

79 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3535

ACCUUUCCACUUCUAAGCCTT

GGCUUAGAAGUGGAAAGGUTT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3539

CUAAGCCUGUUUCUUCCUCTT

GAGGAAGAAACAGGCUUAGTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3543

GAAGAUAGGAAGGGGCUUCTT

GAAGCCCCUUCCUAUCUUCTT

55 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3547

AAUAAGCAGCUCGCGCUCCTT

GGAGCGCGAGCUGCUUAUUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3551

UAGCCAGAGCCAAAGAAGCTT

GCUUCUUUGGCUCUGGCUATT

93 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3555

AACAGUCCUUAGCUACGCUTT

AGCGUAGCUAAGGACUGUUTT

49 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3559

CUAGAGGAUCUUGAAGACCTT

GGUCUUCAAGAUCCUCUAGTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3563

AUCGACCUGAAGGAGUACGTT

CGUACUCCUUCAGGUCGAUTT

52 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3567

GAUAGGAAGGGGCUUCAGCTT

GCUGAAGCCCCUUCCUAUCTT

53 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3571

AGUCCCUGGAGCCUUAAACTT

GUUUAAGGCUCCAGGGACUTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3575

AGCCACAUUUCUAGGAGAUTT

AUCUCCUAGAAAUGUGGCUTT

39 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3579

GAUUCCAAACCCCACUAUCTT

GAUAGUGGGGUUUGGAAUCTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3583

GAUACUUCUGGUUCCCUCCTT

GGAGGGAACCAGAAGUAUCTT

53 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3587

AGAGAAGGGCGUCUCUACATT

UGUAGAGACGCCCUUCUCUTT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3591

AGUUUCUAGGGCCGUGGCCTT

GGCCACGGCCCUAGAAACUTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3595

GAAGAGUUAACCCGGGACUTT

AGUCCCGGGUUAACUCUUCTT

62 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3599

CCGCCCGGCGGCGCCUUUATT

UAAAGGCGCCGCCGGGCGGTT

95 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3603

ACCGACGAUUCUUCUACUCTT

GAGUAGAAGAAUCGUCGGUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3607

GGUAGAAUAGGUUUUCCCCTT

GGGGAAAACCUAUUCUACCTT

54 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3611

UCCCUUCCACCGCCAUAUUTT

AAUAUGGCGGUGGAAGGGATT

58 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3615

CGAGUGUCUAACGGGAGCCTT

GGCUCCCGUUAGACACUCGTT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3619

GACCACGAAGAGUUAACCCTT

GGGUUAACUCUUCGUGGUCTT

91 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3623

AGUUAACCCGGGACUUGGATT

UCCAAGUCCCGGGUUAACUTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3627

AUCACAAACCCCUAGAGGGTT

CCCUCUAGGGGUUUGUGAUTT

35 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3631

AAACCCCUAGAGGGCAAGUTT

ACUUGCCCUCUAGGGGUUUTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3635

UCCGGCUAACUCUGAGGACTT

GUCCUCAGAGUUAGCCGGATT

95 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3639

CGACGAUUCUUCUACUCAATT

UUGAGUAGAAGAAUCGUCGTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3643

UAAACUUUGGGGAAGGGAGTT

CUCCCUUCCCCAAAGUUUATT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3647

AGCGGGGUAUGAAGAGCUUTT

AAGCUCUUCAUACCCCGCUTT

95 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3651

CUCCCCAGUCUCUCUUAAATT

UUUAAGAGAGACUGGGGAGTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3655

GAAUAACCUGAACGUCACCTT

GGUGACGUUCAGGUUAUUCTT

59 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3659

ACGUCACCGAGGAGAAGUATT

UACUUCUCCUCGGUGACGUTT

65 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3663

AGAAGUACCAGGAGGCGUUTT

AACGCCUCCUGGUACUUCUTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3667

AGCCCAGAUAGCUCUUCAGTT

CUGAAGAGCUAUCUGGGCUTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3671

AAACCUCAGCCCUAACGGUTT

ACCGUUAGGGCUGAGGUUUTT

94 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3675

UUAAGGAGAAGCUGACGGCTT

GCCGUCAGCUUCUCCUUAATT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3679

AAGGAACGGGGACACUUACTT

GUAAGUGUCCCCGUUCCUUTT

44 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3683

GGAGCACGCUUACUACCUUTT

AAGGUAGUAAGCGUGCUCCTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3687

GGCGGGCUCUUUCCUAUUCTT

GAAUAGGAAAGAGCCCGCCTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3691

CCGAGAGCUCUCCUACCUUTT

AAGGUAGGAGAGCUCUCGGTT

80 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3695

CUCUCCUACCUUCUCCUCUTT

AGAGGAGAAGGUAGGAGAGTT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3699

CUACCUUCUCCUCUUCUCCTT

GGAGAAGAGGAGAAGGUAGTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3703

AGCCUCCAAACUCCUAGCUTT

AGCUAGGAGUUUGGAGGCUTT

43 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3707

UCCUAGCUGUCUUGUCCCUTT

AGGGACAAGACAGCUAGGATT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3711

AUACUUGGCGGGCUCUUUCTT

GAAAGAGCCCGCCAAGUAUTT

53 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3715

GGGGCUCUUCUACAUUCCCTT

GGGAAUGUAGAAGAGCCCCTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3719

GAGUAUUUCCGCUGGAACUTT

AGUUCCAGCGGAAAUACUCTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3723

GCUGAGGAAAGGGACAUCUTT

AGAUGUCCCUUUCCUCAGCTT

85 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3727

GUACUCUGAUGAGGAAGAGTT

CUCUUCCUCAUCAGAGUACTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3731

GGCCAAAGUAAUCGUGGUUTT

AACCACGAUUACUUUGGCCTT

93 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3735

GUCUAUGCCAAGAAGGGAGTT

CUCCCUUCUUGGCAUAGACTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3739

UCUACACCGCGCCCCCCUCTT

GAGGGGGGCGCGGUGUAGATT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3743

CGCCCCCCUCAAGCUACCGTT

CGGUAGCUUGAGGGGGGCGTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3747

GCUACCGCAACCACGAGCUTT

AGCUCGUGGUUGCGGUAGCTT

47 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3751

CUCCUUCAUUCCAGCCUAUTT

AUAGGCUGGAAUGAAGGAGTT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3755

AGAAAAGCAGCGAUACGCUTT

AGCGUAUCGCUGCUUUUCUTT

78 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3759

GGAGCUAGACGGGUACGAGTT

CUCGUACCCGUCUAGCUCCTT

93 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3763

CGGGUACGAGCCGGAACCUTT

AGGUUCCGGCUCGUACCCGTT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3767

ACGGCUCGCUACCCUCGACTT

GUCGAGGGUAGCGAGCCGUTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3771

AGAGGACCUAGAAGGCGGCTT

GCCGCCUUCUAGGUCCUCUTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3775

AACUCUACUGUGGAGUCGGTT

CCGACUCCACAGUAGAGUUTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3779

AGAAACGCAGUAAUCCGGATT

UCCGGAUUACUGCGUUUCUTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3783

AGUAAUCCGGACUCAACUCTT

GAGUUGAGUCCGGAUUACUTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3787

GAGGAAGAUGAGUUGUACCTT

GGUACAACUCAUCUUCCUCTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3791

AGAUGUUCUCGUAAGGACGTT

CGUCCUUACGAGAACAUCUTT

62 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3795

UCUCGUAAGGACGAAACGATT

UCGUUUCGUCCUUACGAGATT

58 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3799

GCUGUAACCUCGGAGAGUUTT

AACUCUCCGAGGUUACAGCTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3803

CCUCGGAGAGUUCUACUCUTT

AGAGUAGAACUCUCCGAGGTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3807

GCAAGUGGCAAGAGGAUUATT

UAAUCCUCUUGCCACUUGCTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3811

AUGGGAGAAGUAGUCCCCCTT

GGGGGACUACUUCUCCCAUTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3815

AAGUAGUCCCCCUUGAAGATT

UCUUCAAGGGGGACUACUUTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3819

GGUAGGGUUGAAGAGACUUTT

AAGUCUCUUCAACCCUACCTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3823

AGCGCUUAAAGGGCGAGAAGATT

UCUUCUCGCCCUUUAAGCGCUTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3827

GGCCUUUCUCUCUAGAUAUTT

AUAUCUAGAGAGAAAGGCCTT

91 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3831

GCCUCUCUAUCCUUAGCUUTT

AAGCUAAGGAUAGAGAGGCTT

49 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3835

AAGGACCUAGAGGAGUCACTT

GUGACUCCUCUAGGUCCUUTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3839

CUGACCGGAAGCGCUUAAATT

UUUAAGCGCUUCCGGUCAGTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3843

UUAAAGGGCGAGAAGACCGTT

CGGUCUUCUCGCCCUUUAATT

89 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3847

GAAGAGCCUACACAACCCUTT

AGGGUUGUGUAGGCUCUUCTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3851

CUAGAGGAUCUUGAAGACCTT

GGUCUUCAAGAUCCUCUAGTT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3855

ACAUAGAGGAAGACGCGGATT

UCCGCGUCUUCCUCUAUGUTT

91 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3859

AUCGUCGUCAGGGUAAGGUTT

ACCUUACCCUGACGACGAUTT

50 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3863

CUCUGGCCUUUCUCUCUAGTT

CUAGAGAGAAAGGCCAGAGTT

48 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3867

GACAAGGGAAGGUUAGCCUTT

AGGCUAACCUUCCCUUGUCTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3871

AGACUAAGCCCAAAAGGGCTT

GCCCUUUUGGGCUUAGUCUTT

48 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3875

CCUCCCCAUCCCCUUUUAATT

UUAAAAGGGGAUGGGGAGGTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3879

AUCAGAGGGAGGUCUUAGATT

UCUAAGACCUCCCUCUGAUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3883

GGGAGGUCUUAGAAAACACTT

GUGUUUUCUAAGACCUCCCTT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3887

GGCUUAGUCACUCCUCUUCTT

GAAGAGGAGUGACUAAGCCTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3891

ACCUUAAGGACCACCGGAUTT

AUCCGGUGGUCCUUAAGGUTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3895

CGGAUCUACACCUUCAAGATT

UCUUGAAGGUGUAGAUCCGTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3899

UACCGAGAAUGAGCCUGAUTT

AUCAGGCUCAUUCUCGGUATT

57 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3903

GCUUUAAGGAACUGGAAGGTT

CCUUCCAGUUCCUUAAAGCTT

38 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3907

UCCUCGUCGUCUGUUCUAATT

UUAGAACAGACGACGAGGATT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3911

UUCUAACCGGGCAGCUUCUTT

AGAAGCUGCCCGGUUAGAATT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3915

GAGGAUGGAUUCGACUUAGTT

CUAAGUCGAAUCCAUCCUCTT

95 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3919

UAAAGCUGGAAAGGGACGGTT

CCGUCCCUUUCCAGCUUUATT

67 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3923

GGAAGUAAGGACCAGAGACTT

GUCUCUGGUCCUUACUUCCTT

45 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3927

AAGGCCAACCGAUACUUCUTT

AGAAGUAUCGGUUGGCCUUTT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3931

GUUCACGUCCUACCCCUUUTT

AAAGGGGUAGGACGUGAACTT

67 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3935

AGAGUUGGGAUUAGGGCUUTT

AAGCCCUAAUCCCAACUCUTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3939

UUACAAAGGAUCUCCUCCCTT

GGGAGGAGAUCCUUUGUAATT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3943

AACAGCCUUACCCCGAUUCTT

GAAUCGGGGUAAGGCUGUUTT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3947

UUACCCCGAUUCAGCCUCUTT

AGAGGCUGAAUCGGGGUAATT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3951

UAACCCCAAGAACGGGCUUTT

AAGCCCGUUCUUGGGGUUATT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3955

CUAGUCGAAAGAAAACGGGTT

CCCGUUUUCUUUCGACUAGTT

57 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3959

AGGACGGUACUUUCGAAAGTT

CUUUCGAAAGUACCGUCCUTT

46 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3963

GUAUCCGAAGACGAAGCUATT

UAGCUUCGUCUUCGGAUACTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3967

AGAGAGGUGGAGGUAUCUCTT

GAGAUACCUCCACCUCUCUTT

91 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3971

GAAAACGCUUGUAAAGCCGTT

CGGCUUUACAAGCGUUUUCTT

58 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3975

GCUGAACUAGUCGAAAGAATT

UUCUUUCGACUAGUUCAGCTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3979

GGAAGAAGAUAGAGCAUCCTT

GGAUGCUCUAUCUUCUUCCTT

38 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3983

AUCUACCCAGCUCUCCCUUTT

AAGGGAGAGCUGGGUAGAUTT

79 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3987

AGCGAUCCCGAACAAGUAUTT

AUACUUGUUCGGGAUCGCUTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3991

CGAAAGUGUAUCCGAAGACTT

GUCUUCGGAUACACUUUCGTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3995

CCGAAGACGAAGCUAUGAATT

UUCAUAGCUUCGUCUUCGGTT

48 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM3999

UCUCCCACCCAAUGGAGAU

AUCUCCAUUGGGUGGGAGATT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4003

AAACCAGGAAGGGGAAAUCTT

GAUUUCCCCUUCCUGGUUUTT

69 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4007

GAAGGGGAAAUCUGUGGUUTT

AACCACAGAUUUCCCCUUCTT

66 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4011

GGGAGGAUGACAAAGAAGCTT

GCUUCUUUGUCAUCCUCCCTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4015

GAAACUGGUACUUUCCCCCTT

GGGGGAAAGUACCAGUUUCTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4019

AUCGCUGCUCCUCCUCCUCTT

GAGGAGGAGGAGCAGCGAUTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4023

AGCUCUUUGUCACCUCUCUTT

AGAGAGGUGACAAAGAGCUTT

39 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4027

AAUAAGCAGCUCGCGCUCCTT

GGAGCGCGAGCUGCUUAUUTT

58 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4031

CUAGAGGAUCUUGAAGACCTT

GGUCUUCAAGAUCCUCUAGTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4035

AUCGACCUGAAGGAGUACGTT

CGUACUCCUUCAGGUCGAUTT

32 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4039

CCCUCCCCUGUCCCCGCUUTT

AAGCGGGGACAGGGGAGGGTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4043

UUUGAUCAGCGGAGACUCGTT

CGAGUCUCCGCUGAUCAAATT

94 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4047

AGUUAACCCGGGACUUGGATT

UCCAAGUCCCGGGUUAACUTT

93 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4051

AUCACAAACCCCUAGAGGGTT

CCCUCUAGGGGUUUGUGAUTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4055

AAACCCCUAGAGGGCAAGUTT

ACUUGCCCUCUAGGGGUUUTT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4059

GGAACCUCACAUCAACGCGCATT

UGCGCGUUGAUGUGAGGUUCCTT

70 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4063

UGAACGUCACCGAGGAGAATT

UUCUCCUCGGUGACGUUCATT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4067

AACCCAAAGGGGAGUUGCUTT

AGCAACUCCCCUUUGGGUUTT

97 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4071

AAAGGGGAGUUGCUGGAAGTT

CUUCCAGCAACUCCCCUUUTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4075

AAACGUGACUUUGGUUCCUTT

AGGAACCAAAGUCACGUUUTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4079

GAAUAACCUGAACGUCACCTT

GGUGACGUUCAGGUUAUUCTT

72 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4083

ACGUCACCGAGGAGAAGUATT

UACUUCUCCUCGGUGACGUTT

81 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4087

AGAAGUACCAGGAGGCGUUTT

AACGCCUCCUGGUACUUCUTT

62 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4091

AAACCUCAGCCCUAACGGUTT

ACCGUUAGGGCUGAGGUUUTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4095

UUAAGGAGAAGCUGACGGCTT

GCCGUCAGCUUCUCCUUAATT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4099

AACUUCUGGGAGCCUCCAATT

UUGGAGGCUCCCAGAAGUUTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4103

CCAGCGAGCCCAAAAGAAATT

UUUCUUUUGGGCUCGCUGGTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4107

CUCAAAUCAAGGCCGGAGUTT

ACUCCGGCCUUGAUUUGAGTT

86 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4111

AGCCUCCAAACUCCUAGCUTT

AGCUAGGAGUUUGGAGGCUTT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4115

AUACUUGGCGGGCUCUUUCTT

GAAAGAGCCCGCCAAGUAUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4119

UUGGGGAAGCGGCCGGCGGTT

CCGCCGGCCGCUUCCCCAATT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4123

AAGGCAUGCUUCGGAAACUTT

AGUUUCCGAAGCAUGCCUUTT

96 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4127

GCUUCGGAAACUGGACAUCTT

GAUGUCCAGUUUCCGAAGCTT

91 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4131

AACUCUACUGUGGAGUCGGTT

CCGACUCCACAGUAGAGUUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4135

AGAAACGCAGUAAUCCGGATT

UCCGGAUUACUGCGUUUCUTT

87 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4139

GGAAGUCCACCUUCUCCGATT

UCGGAGAAGGUGGACUUCCTT

55 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4143

CUCCGACAGAUGAAGGAAATT

UUUCCUUCAUCUGUCGGAGTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4147

AAGGACCUAGAGGAGUCACTT

GUGACUCCUCUAGGUCCUUTT

83 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4151

CUGACCGGAAGCGCUUAAATT

UUUAAGCGCUUCCGGUCAGTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4155

GAAGAGCCUACACAACCCUTT

AGGGUUGUGUAGGCUCUUCTT

76 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4159

ACAGAAAGAGUUCGAGGAGTT

CUCCUCGAACUCUUUCUGUTT

65 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4163

AGGAGACCGUGACAUUUCGTT

CGAAAUGUCACGGUCUCCUTT

0 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4167

ACCUUAAGGACCACCGGAUTT

AUCCGGUGGUCCUUAAGGUTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4171

CGGAUCUACACCUUCAAGATT

UCUUGAAGGUGUAGAUCCGTT

44 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4175

GCUUUAAGGAACUGGAAGGTT

CCUUCCAGUUCCUUAAAGCTT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4179

GAGAGAGACGGUGGAAGAATT

UUCUUCCACCGUCUCUCUCTT

75 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4183

AUCCUGCAGAAGAAGCCUCTT

GAGGCUUCUUCUGCAGGAUTT

53 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4187

UCCUCGUCGUCUGUUCUAATT

UUAGAACAGACGACGAGGATT

84 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4191

AACCCACCACAGCUAGAACUU

GUUCUAGCUGUGGUGGGUUUU

89 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4195

UUACAAAGGAUCUCCUCCCTT

GGGAGGAGAUCCUUUGUAATT

77 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4199

AAACGAGAGAGCCCACCUUTT

AAGGUGGGCUCUCUCGUUUTT

58 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4203

AAAGCGGUGGAUCAGCUCUTT

AGAGCUGAUCCACCGCUUUTT

69 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4207

UCCAAGCUUCCUCGUUGGUTT

ACCAACGAGGAAGCUUGGATT

71 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4211

AGAGAGGUGGAGGUAUCUCTT

GAGAUACCUCCACCUCUCUTT

90 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4215

CCGAAGACGAAGCUAUGAATT

UUCAUAGCUUCGUCUUCGGTT

73 percent target mRNA inhibition

13 nM

US20120088815A1, EP2415869A1

SM4231

AACCUUACCCACCUCAUGUAUCU

AGAUACAUGAGGUGGGUAAGGUU

86 percent target mRNA inhibition

17 nM

25233814

SM4250

AACCUUACCCACCUCAUGUAUCU

AGAUACAUGAGGUGGGUAAGGUU

97 percent target mRNA inhibition

17 nM

25233814

SM4297

AAGUAAGGACCAGAGACAAA

UUUGUCUCUGGUCCUUACUU

55 percent target mRNA inhibition

1.5 nM

15974578

SM4452

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

82 percent target mRNA inhibition

1 nM

21985606

SM4457

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

0 percent target mRNA inhibition

100 nM

21985606

SM4460

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

50 percent target mRNA inhibition

50 uM

21985606

SM4466

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

35 percent target mRNA inhibition

50 uM

21985606

SM4472

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

0 percent target mRNA inhibition

1 uM

21985606

SM4478

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

0 percent target mRNA inhibition

1 uM

21985606

SM4533

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

58 percent target mRNA inhibition

0.2 nM

22236254

SM4597

GGCCUUUCACUACUCCUACTT

AGUAGGAGUAGUGAAAGGCCTT

97 percent target mRNA inhibition

33 nM

22372696

SM4606

UAAGGCUAUGAAGAGAUACTT

AGUAUCUCUUCAUAGCCUUATT

1 percent target mRNA inhibition

33 nM

22372696

SM4607

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

NA

NA

22494497

SM4608

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

NA

NA

22494497

SM4615

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

NA

NA

22494497

SM4616

CUUCCUACAGCACAACAAAUGUGAAUG

CAUUCACAUUUGUUGUGCUGUAGGAAG

NA

NA

22494497

SM4619

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

82 percent target mRNA inhibition

1 nM

22494497

SM4623

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

80 percent target mRNA inhibition

1 nM

22494497

SM4627

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

58 percent target mRNA inhibition

0.2 nM

22494497

SM4631

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

69 percent target mRNA inhibition

0.2 nM

22494497

SM4635

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

12 percent target mRNA inhibition

600 nM

22494497

SM4639

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

0 percent target mRNA inhibition

600 nM

22494497

SM4643

GGCCUUUCACUACUCCUACGA

GUAGGAGUAGUGAAAGGCCAG

0 percent target mRNA inhibition

50 nM

22494497

SM4647

CUGGCCUUUCACUACUCCUACGAGCAC

GUGCUCGUAGGAGUAGUGAAAGGCCAG

0 percent target mRNA inhibition

50 nM

22494497

SM4651

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

75 percent target mRNA inhibition

100 nM

22494497

SM4653

CUUCCUACAGCACAACAAAUGUGAAUG

CAUUCACAUUUGUUGUGCUGUAGGAAG

90 percent target mRNA inhibition

100 nM

22494497

SM4655

UCCUACAGCACAACAAAUGUG

CAUUUGUUGUGCUGUAGGAAG

13 percent target mRNA inhibition

100 nM

22494497

SM4657

CUUCCUACAGCACAACAAAUGUGAAUG

CAUUCACAUUUGUUGUGCUGUAGGAAG

36 percent target mRNA inhibition

100 nM

22494497

SM4659

CUUACGCUGAGUACUUCGATT

UCGAAGUACUCAGCGUAAGTT

96 percent target mRNA inhibition

13 nM

US 20080249039 A1

SM4679

NNNNNNNNNNNNNNNNNNNNNN

NNNNNNNNNNNNNNNNNNNNNN

70 percent target mRNA inhibition

30 nM

EP2548962A1

SM4688

NNNNNNNNNNNNNNNNNNNNNN

NNNNNNNNNNNNNNNNNNNNNN

55 percent target mRNA inhibition

30 nM

EP2548962A1

SM4828

UGAAUCAGAAGAUGAAGUCAA

GACUUCAUCUUCUGAUUCAAG

60 percent target mRNA inhibition

2 nmol/l

23820891

SM4832

UGAAUCAGAAGAUGAAGUCAA

GACUUCAUCUUCUGAUUCAAG

94 percent target mRNA inhibition

2 nmol/l

23820891

SM4836

UAACUAGAGAUCCCUCAGACC

UCUGAGGGAUCUCUAGUUACC

IC-50 1.6 (pmol/l) for target mRNA

NA

23820891

SM4837

GUAACUAGAGAUCCCUCAGAC

CUGAGGGAUCUCUAGUUACCA

IC-50 0.8(pmol/l) for target mRNA

NA

23820891

SM4838

AACUAGAGAUCCCUCAGACCC

GUCUGAGGGAUCUCUAGUUAC

IC-50 2.3 (pmol/l) for target mRNA

NA

23820891

SM4855

GCGCGCUUUGUAGGAUUCGTT

CGAAUCCUACAAAGCGCGCTT

0 percent target mRNA inhibition

25 nM

15919084

SM4856

CGUACGCGGAAUACUUCGATT

UCGAAGUAUUCCGCGUACGTT

95.4 percent target mRNA inhibition (IC-50 = 0.10 nM)

25 nM

15919084

SM4877

CGUACGCGGAAUACUUCGATT

UCGAAGUAUUCCGCGUACGTT

95.4 percent target mRNA inhibition

25 nM

17150641

SM4885

AAACAUGCAGAAAAUGCUGTT

CAGCAUUUUCUGCAUGUUUTT

41.7 percent target mRNA inhibition

25 nM

17150641

SM4893

CGUACGCGGAAUACUUCGATT

UCGAAGUAUUCCGCGUACGTT

95.4 percent target mRNA inhibition

25 nM

17924376

SM4912

CGUACGCGGAAUACUUCGATT

UCGAAGUAUUCCGCGUACGTT

95.4 percent target mRNA inhibition

25 nM

17924376

SM4932

AAACAUGCAGAAAAUGCUGTT

CAGCAUUUUCUGCAUGUUUTT

41.7 percent target mRNA inhibition

25 nM

17924376

SM4951

AAACAUGCAGAAAAUGCCUTT

CAGCAUUUUCUGCAUGUUUTT

69.7 percent target mRNA inhibition

25 nM

17924376