Enantiocomplementary reduction of 3-phenylthiopropan-2-one by Bacillus sp.: effect of medium components.

Rampal, Poonam and Saini, H S and Raj, Mayil and Chimni, Swapandeep Singh and Chadha, Bhupinder Singh (2007) Enantiocomplementary reduction of 3-phenylthiopropan-2-one by Bacillus sp.: effect of medium components. Bioresource technology, 98 (3). pp. 725-8. ISSN 0960-8524

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Abstract

The enantioselectivity of the enzymes responsible for reduction of prochiral compound 3-phenylthiopropan-2-one was dependent on the concentration of yeast extract and glucose in the growth medium. Low concentrations of yeast extract (0.1-0.9% w/v) favored the formation of S-enantiomer (62% ee at 0.1% w/v yeast extract) of 3-phenylthiopropan-2-ol. However, R-enantiomer of the reduced product was formed when MSM was supplemented with yeast extract at a concentration of 1% (w/v) or more with a maximum ee of 85% at 2.0% (w/v) yeast extract supplement in the growth medium.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Elsevier Science.
Uncontrolled Keywords:	Asymmetric reduction; Enantioselectivity; Yeast extract
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	17 Feb 2012 16:44
Last Modified:	09 Jan 2015 11:20
URI:	http://crdd.osdd.net/open/id/eprint/1021

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