TAPPred prediction of TAP-binding peptides in antigens.

Bhasin, Manoj and Lata, Sneh and Raghava, G.P.S. (2007) TAPPred prediction of TAP-binding peptides in antigens. Methods in molecular biology (Clifton, N.J.), 409. pp. 381-6. ISSN 1064-3745

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Abstract

The transporter associated with antigen processing (TAP) plays a crucial role in the transport of the peptide fragments of the proteolysed antigenic or self-altered proteins to the endoplasmic reticulum where the association between these peptides and the major histocompatibility complex (MHC) class I molecules takes place. Therefore, prediction of TAP-binding peptides is highly helpful in identifying the MHC class I-restricted T-cell epitopes and hence in the subunit vaccine designing. In this chapter, we describe a support vector machine (SVM)-based method TAPPred that allows users to predict TAP-binding affinity of peptides over web. The server allows user to predict TAP binders using a simple SVM model or cascade SVM model. The server also allows user to customize the display/output. It is freely available for academicians and noncommercial organization at the address http://www.imtech.res.in/raghava/tappred.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Springer Science
Subjects:	Q Science > QH Natural history > QH301 Biology QH301 Biology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	08 Dec 2011 19:39
Last Modified:	08 Dec 2011 19:39
URI:	http://crdd.osdd.net/open/id/eprint/596

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