Distinct Strategies Employed by Dendritic Cells and Macrophages in Restricting Mycobacterium tuberculosis Infection: Different Philosophies but Same Desire.

Khan, Nargis and Vidyarthi, Aurobind and Pahari, Susanta and Agrewala, J N (2015) Distinct Strategies Employed by Dendritic Cells and Macrophages in Restricting Mycobacterium tuberculosis Infection: Different Philosophies but Same Desire. International reviews of immunology. ISSN 1563-5244

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Abstract

Dendritic cells (DCs) and macrophages (Mφs) are professional antigen-presenting cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). It is quite interesting to mention here that DCs and Mφs use distinct strategies to combat and eliminate Mtb. Similarly, Mtb employs different mechanisms to counteract the action of DCs and Mφs. Mφs are evolved with specialized, innate, defensive machinery to restrict growth of Mtb at the initial phase of infection. However, DCs are more endowed toward initiating adaptive immunity by activating naïve T cells. During encounter with Mtb, DCs and Mφs deliver discrete functions via triggering through different pattern recognition receptors (PRRs) expressed by these APCs. Mtb-infected DCs and Mφs show differential expression of genes encoding cytokines, chemokines, costimulatory molecules, and adhesion molecules. Interestingly, Mtb impairs the immune defensive machinery by exploiting various PRRs. Remarkably, selective signaling through PRRs by Mtb abrogates the bactericidal activity of Mφs, but subverts differentiation of monocytes to DCs. In this article, we highlight the role of PRRs in inducing distinct immune response by DCs and Mφs against Mtb. Concurrently, we also discuss smart strategies exploited by Mtb to impair the function of host DCs and Mφs.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Informahealthcare.
Uncontrolled Keywords:	Mycobacterium tuberculosis; chemokines; cytokines; dendritic cells; macrophages; pattern recognition receptors
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	13 Jul 2015 11:04
Last Modified:	22 Jul 2015 04:20
URI:	http://crdd.osdd.net/open/id/eprint/1642

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