Chopra, Lipsy and Singh, Gurdeep and Kumar Jena, Kautilya and Sahoo, Debendra K (2015) Sonorensin: A new bacteriocin with potential of an anti-biofilm agent and a food biopreservative. Scientific reports, 5. p. 13412. ISSN 2045-2322
Full text not available from this repository. (Request a copy)Abstract
The emergence of antibiotic resistant bacteria has led to exploration of alternative therapeutic agents such as ribosomally synthesized bacterial peptides known as bacteriocins. Biofilms, which are microbial communities that cause serious chronic infections, form environments that enhance antimicrobial resistance. Bacteria in biofilm can be upto thousand times more resistant to antibiotics than the same bacteria circulating in a planktonic state. In this study, sonorensin, predicted to belong to the heterocycloanthracin subfamily of bacteriocins, was found to be effectively killing active and non-multiplying cells of both Gram-positive and Gram-negative bacteria. Sonorensin showed marked inhibition activity against biofilm of Staphylococcus aureus. Fluorescence and electron microscopy suggested that growth inhibition occurred because of increased membrane permeability. Low density polyethylene film coated with sonorensin was found to effectively control the growth of food spoilage bacteria like Listeria monocytogenes and S. aureus. The biopreservative effect of sonorensin coated film showing growth inhibition of spoilage bacteria in chicken meat and tomato samples demonstrated the potential of sonorensin as an alternative to current antibiotics/ preservatives.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to NPG |
| Uncontrolled Keywords: | Anti-biofilm agent |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 29 Jan 2016 04:09 |
| Last Modified: | 29 Jan 2016 04:09 |
| URI: | http://crdd.osdd.net/open/id/eprint/1756 |
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