Gowthaman, Uthaman and Mushtaq, Khurram and Tan, Amabel C and Rai, Pradeep K and Jackson, David C and Agrewala, Javed N (2015) Challenges and solutions for a rational vaccine design for TB-endemic regions. Critical reviews in microbiology, 41 (3). pp. 389-98. ISSN 1549-7828
Full text not available from this repository. (Request a copy)Abstract
Vaccines have been successful for global eradication or control of dreaded diseases such as smallpox, diphtheria, tetanus, yellow fever, whooping cough, polio, and measles. Unfortunately, this success has not been achieved for controlling tuberculosis (TB) worldwide. Bacillus Calmette Guérin (BCG) is the only available vaccine against TB. Paradoxically, BCG has deciphered success in the Western world but has failed in TB-endemic areas. In this article, we highlight and discuss the aspects of immunity responsible for controlling Mycobacterium tuberculosis infection and factors responsible for the failure of BCG in TB-endemic countries. In addition, we also suggest strategies that contribute toward the development of successful vaccine in protecting populations where BCG has failed.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Informa UK. |
| Uncontrolled Keywords: | TB; T cell memory; Endemic areas; Vaccine; BCG |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 28 Jan 2016 07:21 |
| Last Modified: | 28 Jan 2016 07:21 |
| URI: | http://crdd.osdd.net/open/id/eprint/1778 |
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