Sengupta, Chirantana and Ekka, Manjula and Arora, Saurabh and Dhaware, Prashant D. and Chowdhury, Rukhsana and Raychaudhuri, Saumya (2017) Cross feeding of glucose metabolism byproducts of Escherichia coli human gut isolates and probiotic strains affect survival of Vibrio cholerae. Gut Pathogens, 9 (3). ISSN 1757-4749
Full text not available from this repository. (Request a copy)Abstract
Vibrio cholerae converts glucose into either acid or the neutral end product acetoin and its survival in carbohydrate enriched media is linked to the nature of the byproducts produced. It has been demonstrated in this study that Escherichia coli strain isolated from the gut of healthy human volunteers and the commonly used probiotic E. coli Nissle strain that metabolize glucose to acidic byproducts drastically reduce the survival of V. cholerae strains irrespective of their glucose sensitivity and acetoin production status. Accordingly, E. coli glucose transport mutants that produce lower amounts of acidic metabolites had little effect on the survival of V. cholerae in cocultures. Thus, cross feeding of byproducts of glucose metabolism by heterologous bacteria modulates the survival of V. cholerae in glucose rich medium suggesting that composition of the gut microbiota could influence the outcome of V. cholerae infection especially when glucose based ORS is administered.
| Item Type: | Article |
|---|---|
| Additional Information: | Open Access |
| Uncontrolled Keywords: | V. cholerae survival, Cocultures, E. coli Nissle 1917, E. coli glucose transport mutants |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 24 Mar 2018 03:38 |
| Last Modified: | 31 Oct 2018 06:35 |
| URI: | http://crdd.osdd.net/open/id/eprint/1989 |
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