Gujar, Ravindra and Sen, Pradip (2018) Transforming growth factor-β1 impairs lymph node homing of dendritic cells by downregulating C-type lectin receptor-2 expression. Cytokine, 110. pp. 39-43.
Full text not available from this repository. (Request a copy)Abstract
Trafficking of dendritic cells (DCs) from peripheral tissues to draining lymph nodes is a prerequisite for induction of adaptive immunity. An immunosuppressive cytokine transforming growth factor (TGF)-β1, however, inhibits migration of DCs by downregulating the expression of chemokine receptor CCR-7. Whether TGF-β1 engages any other receptor to mediate this inhibitory effect is currently unknown. In this article, we report that TGF-β1 attenuated the lymph node homing ability of mouse DCs by reducing C-type lectin receptor-2 (CLEC-2) expression. Notably, TGF-β1 inhibited CLEC-2 expression in DCs via c-Src. DCs silenced for c-Src were resistant to TGF-β1-induced inhibition of CLEC-2 expression. Furthermore, silencing of c-Src substantially improved the lymph node homing capacity of TGF-β1-treated DCs by restoring CLEC-2 expression. These results document a critical role for c-Src and CLEC-2 in TGF-β1-mediated impairment of DC migration and define a previously unknown mechanism by which TGF-β1 attenuates the lymph node homing ability of DCs.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Elsevier Science. |
| Uncontrolled Keywords: | C-type lectin receptor; Dendritic cell trafficking; Immunosuppressive cytokines; c-Src |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 15 Jun 2018 10:12 |
| Last Modified: | 20 Mar 2019 09:36 |
| URI: | http://crdd.osdd.net/open/id/eprint/2089 |
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