Nag, Dhrubajyoti and Breen, Paul and Raychaudhuri, Saumya and Withey, Jeffrey H (2018) Glucose metabolism by inhibits intestinal colonization of zebrafish. Infection and immunity. ISSN 1098-5522
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The O1 serogroup is responsible for pandemic cholera and is divided into the classical and El Tor biotypes. Classical produces acid when using glucose as a carbon source, whereas El Tor produces the neutral product acetoin when using glucose as a carbon source. An earlier study demonstrated that strains that metabolize glucose to acidic by-products drastically reduced the survival of strains in vitro. In the present study, zebrafish were fed 1% glucose and inoculated with single or strains or co-infected with both and A significant decrease in classical biotype colonization was observed after glucose feeding due to acid production in the zebrafish intestine. El Tor colonization was unaffected by glucose alone. However, the El Tor strain exhibited significantly lower colonization of the zebrafish when either of the acid producing was co-inoculated in the presence of glucose. An sugar transport mutant had no effect on colonization even in presence of glucose. Glucose and produced a prophylactic effect on El Tor colonization in zebrafish when was inoculated before infection. Thus, the probiotic feeding of inhibits colonization in a natural host. This suggests that a similar inhibitory effect could be seen in cholera patients, especially if glucose-based oral rehydration solution (ORS) is administered in combination with probiotic during cholera treatment.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to American Society for Microbiology. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 04 Oct 2018 10:20 |
| Last Modified: | 04 Oct 2018 10:20 |
| URI: | http://crdd.osdd.net/open/id/eprint/2125 |
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