Sajid, Mohammad and Agrewala, J N (2018) Low prevalence of anti-xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer. Cancer medicine, 8 (1). pp. 246-260. ISSN 2045-7634
Full text not available from this repository. (Request a copy)Abstract
Cancer is one of the major health problem globally, responsible for high morbidity and mortality. Exposure of humans to xenobiotics is associated with the development of cancer. Further, these xenobiotics may combine with the body proteins and can act as a hapten and elicit an antibody response. In this study, we examined whether the regular exposer to xenobiotics evokes anti-xenobiotic antibodies and the presence of these antibodies have any correlation with the prevention of cancer. Interestingly, we noticed that the healthy household contacts showed significantly greater titers of anti-xenobiotic antibodies, as compared to cancer patients. Consequently, suggesting that the higher level of anti-xenobiotic antibodies may be responsible for neutralizing the effect of xenobiotics in the healthy subjects. Thereby, preventing the individuals from disease. In contrast, the presence of a significantly lower level of anti-xenobiotic antibodies in the cancer patients may be a causative factor for disease infliction. In conclusion, immunotherapy employing anti-xenobiotic antibodies may provide a prudent remedial measure to clear xenobiotics from the body of the individuals and thereby protecting from cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anti-xenobiotic antibodies; breast cancer; cancer; household contacts; pesticides; xenobiotics |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 19 Mar 2019 15:18 |
| Last Modified: | 19 Mar 2019 15:18 |
| URI: | http://crdd.osdd.net/open/id/eprint/2131 |
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