Dilawari, Rahul and Chaubey, Gaurav Kumar and Modanwal, Radheshyam and Dhiman, Asmita and Talukdar, Sharmila and Kumar, Ajay and Raje, Chaaya Iyengar and Raje, Manoj (2024) Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells. JOURNAL OF INNATE IMMUNITY, 16 (1). pp. 133-142.
Full text not available from this repository. (Request a copy)Abstract
Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term after effects. Virus entry into host cells involves interaction between receptor-binding domain (RBD) of spike (S) protein S1 subunit with angiotensin converting enzyme present on host cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a moonlighting enzyme involved in cellular glycolytic energy metabolism and micronutrient homeostasis. It is deployed in various cellular compartments and the extra cellular milieu. Though it is known to moonlight as a component of mammalian innate immune defense machinery, till date its role in viral restriction remains unknown.
| Item Type: | Article |
|---|---|
| Additional Information: | The copyright of this article belongs to KARGER |
| Uncontrolled Keywords: | ACE2; GAPDH; Inhibition; Innate immune defense; Severe acute respiratory syndrome coronavirus-2. |
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 24 Jun 2024 03:13 |
| Last Modified: | 24 Jun 2024 03:13 |
| URI: | http://crdd.osdd.net/open/id/eprint/3112 |
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