Agrewala, J N and Owais, M and Gupta, C M and Mishra, G C (1996) Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells. Cytokines and molecular therapy, 2 (1). pp. 59-65. ISSN 1355-6568
Full text not available from this repository. (Request a copy)Abstract
Liposomes have been used to modify the immunological behaviour of a number of antigens. The present study was designed to evaluate the effect of liposomization of ovalbumin on the induction of Th-1 and Th-2-cell response by monitoring the secretion of lymphokines and IgG Isotypes. Liposomes having varied physicochemical properties (positively and negatively charged, neutral and pH-sensitive) were used for this purpose. Ovalbumin delivered in this way induced preferential secretion of IL-4 and production of antigen-specific IgG1 isotypes. This was observed irrespective of the surface charge properties of the liposomes. Further, the concentration of antigen required for the activation of Th cells was 10(2)- to 10(3)-fold lower after encapsulating it in liposomes. These results suggest that liposomes may prove useful adjuvants to prime Th2-like immune responses.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright of this article belongs to Martin Dunitz Publishers. |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Depositing User: | Dr. K.P.S.Sengar |
| Date Deposited: | 13 Dec 2011 16:47 |
| Last Modified: | 13 Dec 2011 16:47 |
| URI: | http://crdd.osdd.net/open/id/eprint/384 |
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