Majumder, S and Gupta, R (1994) Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells. FEMS microbiology letters, 120 (3). pp. 329-34. ISSN 0378-1097

PDF majumdar94.pdf - Published Version Restricted to Registered users only Download (389Kb) | Request a copy

Abstract

The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.

Item Type:	Article
Additional Information:	Copyright of this article belongs to Elsevier Science
Uncontrolled Keywords:	Mycobacterium microti; Interleukin-1 a; Mycobacteria; Cyclic AMP
Subjects:	Q Science > QR Microbiology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	13 Dec 2011 16:51
Last Modified:	13 Dec 2011 16:51
URI:	http://crdd.osdd.net/open/id/eprint/406

Actions (login required)

View Item