Banerjee, U C and Saxena, B and Chisti, Y. (1992) Biotransformations of rifamycins: process possibilities. Biotechnology advances, 10 (4). pp. 577-95. ISSN 0734-9750
PDF
banerjee92.pdf - Published Version Restricted to Registered users only Download (766Kb) | Request a copy |
Abstract
Rifampicin, an important antibiotic, is manufactured by chemical conversion of rifamycin S which is obtained by the chemical modification of rifamycin B. Rifamycin B is a product of Nocardia mediterranei fermentations. The chemical conversion of rifamycin B to rifamycin S has many disadvantages: Strong acidic conditions are required, heavy foam formation accompanies transformation and the yields are low. This review highlights the developments in alternative, biochemical transformations using enzymes and cells; the main focus is on transformations carried out by rifamycin oxidase.
Item Type: | Article |
---|---|
Additional Information: | Copyright of this article belongs to Elsevier Science |
Subjects: | Q Science > QD Chemistry |
Depositing User: | Dr. K.P.S.Sengar |
Date Deposited: | 12 Dec 2011 15:38 |
Last Modified: | 29 Mar 2012 06:48 |
URI: | http://crdd.osdd.net/open/id/eprint/425 |
Actions (login required)
View Item |