T cell help to B cells in germinal centers: putting the jigsaw together.

Gowthaman, Uthaman and Chodisetti, Sathi Babu and Agrewala, J N (2010) T cell help to B cells in germinal centers: putting the jigsaw together. International reviews of immunology, 29 (4). pp. 403-20. ISSN 1563-5244

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Official URL: http://informahealthcare.com/doi/abs/10.3109/08830...

Abstract

The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.

Item Type: Article
Additional Information: Copyright of this article belongs to Informa Healthcare
Uncontrolled Keywords: follicular T helper cells; B cells, germinal centers; T cell subsets
Subjects: Q Science > QR Microbiology > QR180 Immunology
Depositing User: Dr. K.P.S.Sengar
Date Deposited: 08 Dec 2011 18:59
Last Modified: 07 Jan 2015 04:57
URI: http://crdd.osdd.net/open/id/eprint/505

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