Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes.

Vijayakrishnan, L and Kumar, V and Agrewala, J N and Mishra, G C and Rao, K V (1994) Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes. Journal of immunology (Baltimore, Md. : 1950), 153 (4). pp. 1613-25. ISSN 0022-1767

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Abstract

Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Inversion of immunodominance correlated with the inability of anti-MEP 77-100 B cells to interact productively with T cells, which consequently received reduced help. Interaction between epitope-specific B and T cells was found to be attenuated in the presence of early primary anti-MEP-1 antiserum, and the extent of inhibition was directly proportional to the level and affinity of epitope-specific Igs. Therefore, it seems that early primary Abs to a multideterminant Ag selectively down-regulate maturation of epitope-specific primary humoral responses.

Item Type:	Article
Additional Information:	Copyright of this article belongs to American Association of Immunologists.
Subjects:	Q Science > QR Microbiology > QR355 Virology
Depositing User:	Dr. K.P.S.Sengar
Date Deposited:	27 Jan 2012 15:35
Last Modified:	27 Jan 2012 15:35
URI:	http://crdd.osdd.net/open/id/eprint/706

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