Development of computational resources and pipeline for predicting and designing therapeutic peptides. Prediction and optimization of peptide's properties (such as half-life, immunogenicity, toxicity, MIC, etc) that may help in designing highly drug-like peptides. Moreover, my objective is to remain abreast with the latest advances in Bioinformatics and best utilize biological, programming and analytical knowledge in a sound working environment.
Current Position::
Currently working as CSIR- Sr. Research Fellow at Open Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research (CSIR), New Delhi, India.
Work Experience::
Served under the DBT sponsored project "Bioinformatics: Protein Engineering and Design". Worked as Project Assistant (Level . II) on DBT funded project entitled "Bioinformatics: Protein Engineering & Design" under the supervision of Dr. G. P. S. Raghava (Scientist and Head, Bioinformatics Centre, Institue of Microbial Technology, Sec- 39A, Chandigarh, India). He has developed a number of databases (using PHP and MySQL), SVM based prediction methods and therapeutic peptide designing tools/softwares.
An Interview with OSDD members during OSCAT-2012
Publications::
1. Gaur, A.S., Bhardwaj, A., Sharma, A. et al. J Chem Sci (2017). doi:10.1007/s12039-017-1268-4
2. Sharma, A. et al. dPABBs: A Novel in silico Approach for Predicting and Designing Anti-biofilm Peptides. Sci. Rep. 6, 21839. doi: 10.1038/srep21839 (2016).
3. Sharma et al.: BioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts. Journal of Cheminformatics 2014 6:46.
4. Sharma A, Singla D, Rashid M. and Raghava G.P.S. (2014) Designing of peptides with desired half-life in intestine-like environment. BMC Bioinformatics 2014, 15:282.
7. Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, et al. (2012) Crowd Sourcing a New Paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis. PLoS ONE 7(7): e39808.
9. Tyagi A#, Ahmed F#, Thakur N, Sharma A, Raghava GPS, et al. (2011) HIVsirDB: A Database of HIV Inhibiting siRNAs. PLoS ONE 6(10): e25917. doi:10.1371/journal.pone.0025917
He completed B.Sc. in General (Botany, Zoology, Chemistry) from Kurukshetra University Kurukshetra (2002-05) and M.Sc. in Bioinformatics from Chaudhary Charan Singh Haryana Agricultural University, Hisar (2006-08).
