Combinatorial chemistry and analog generation

Combinatorial chemistry is a method of synthesizing many different and large numbers of substances quickly. It synthesize large number of chemical compounds by combining sets of building blocks.

List of freely available tools:

Database	Description
SmiLib	SmiLib is a freely available Linux based tool can be used as command line and graphical user inferface for generating combinatorial library. It requires three substructures: Scaffolds, Building blocks and Linkers to generate a combinatorial library.
CLEVER	Chemical Library Editing, Visualizing and Enumerating Resource (CLEVER) is a free tool that enumerates chemical libraries using customized fragments and used in computes the physicochemical properties of generated molecules.
GLARE	Global Library Assessment of REagents (GLARE) is an ppen source package to generate the combinatorial library.
Newlead	It is used for the automatic generation of combinatorial library from bioactive conformations of reference molecules.
Library synthesizer	It is java based tool for chemical library enumeration and profiling.
ChemT	An open-source software tool that automates the process of preparing custom-made template-based chemical libraries.
AutoClickChem	It is used to produce large combinatorial libraries of compound models for use in virtual screens.

List of freely available tools:

Database	Description
PGVL Hub	It is a tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds.
PICCOLO	Combinatorial library design tool based on using a weighted sum optimization technique.
MoSELECT	MoSELECT is a program for the design of combinatorial libraries optimised on multiple objectives.
LoFT	LoFT tool used for focused combinatorial library design. It constructing a focused library from a chemical fragment space under optimization of multiple design criteria.
PLUMS	A program to perform rational monomer selection for combinatorial chemistry libraries
LeadGrow	LeadGrow provides features for focused combinatorial library generation and screening to grow a lead molecule and generate large number of possibilities for lead optimization.