| Gene Name |
Pubmed ID |
Classification |
Sample Location |
Remark |
| FHIT | 19730990 | - | - | Point mutation of FHIT gene play a pivotal role in cervical carcinoma |
| FHIT | 19471558 | Methylation | Kyung Hee University Hospital, Seoul. | FHIT inactivation in cervical cancer is found to be strongly correlated with 5'-CpG island hypermethylation. FHIT gene is down-regulated in 15 of 58 (25.9%) cervical carcinomas. |
| FHIT | 18608185 | Methylation | Department of Gynecology, JawaharLal Nehru Medical College and Hospital, Aligarh | Aberrant methylation of FHIT gene is found in 28.3% cases of cervix cancer. |
| FHIT | 17596760 | - | Perola Byington Hospital, Sao Paulo, Brazil | The FHIT gene loss of heterozygosity is found to be significantly associated with onocgenic HPV infection, and FHIT deletion is most commonly present in 47% of the invasive carcinoma of the cervix. |
| FHIT | 17137614 | Methylation | Department of Pathology, Seoul National University Hospitla. | FHIT expression is significantly associated with nodal status (P=0.002), histologic grade (P=0.000). Abnormal FHIT expression in invasive cervical adenocarcinoma, associate with tumor aggressiveness |
| FHIT | 17009983 | Methylation | Central Hospital of Gynecology and Obsterics, Tianjin, China | Higher rate of CpG island methylation within FHIT gene is associated with higher clinical stage and histologic grade of cervix cancer. Methylation of FHIT gene is detected inn 30.46% of plasam samples of cervical patients. Thus methylation of FHITgene in plasma samples will become a sensitive marker for the detection of cervical cancers. And methylation of this gene influences the genesis and progression of cervical cancer. |
| FHIT | 11297252 | Methylation | Parkland Health and Hospital System, Dallas, Texas. | The methylation of FHIT is absent in preinvasive lesion but is frequent in invasive tumors (32%, P=0.002). |
| FHIT | 17467893 | Methylation | Samsung Medical School, Seoul, Korea | The high frequency of promoter hypermethylation in cervical carcinoma suggests that they play a role in the development of cervical squamous cell carcinoma. The frequency of hypermethylation for FHIT in cervical carcinoma have been reported to be 11-88%. |
| FHIT | 12702579 | Methylation | Anatomical Pathology Department of the City of Hope National Medical Center. | Aberrant methylation of CpG island within the promoter regions has been observed in the 25-50% of the tumors. |
| FHIT | 17306351 | Overexpression | Clinic of Obstetrics and Gynaecology at the Medical University of Vienna, Austria. | FHIT protoncogene showed a 1.80 fold higher in malignant HR-HPV(-)cervical squamous cells |
| FHIT | 19730990 | Mutation | Jawahar Lal Nehru Medical College and Hospital, Aligarh. | A novel mutation identified at nucleotide position 655, at codon 98 from CAT to CGT with ultimate replacement of amino acid His by Arg in cervical cancer cases. |
| FHIT | 15589597 | Methylation | Department of Obstertics and Gynecology, Seoul national University Hospital. | Frequency of methylation of FHIT is found to be 79.3%. |
| FHIT | 11301476 | - | - | Inactivation of FHIT on chromosome 3p is involved in cervical carcinogenesis. |
| FHIT | 12773202 | Methylation | - | A high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes |
| FHIT | 14660280 | Methylation | - | 5'-CpG island methylation of the FHIT gene was detected in 40% (16/40) of the cervical cancer samples and in none of normal cervical epithelial specimens |