CCDB

1.Total Number of non-redundant genes and references in CCDB

Total No. of Genes	Total No. of References
537	192

2.Aberrant Biological Process in which cervical cancer genes are indulged as per literature.

3.Gene Ontology Classification

a)Molecular Class

b)Molecular Function

c)Biological Process

4.Chromosome wise classification of genes

Chromosome	Number of non-redundant Genes	Gene Name
Chromosome 1	48	AIM2, BAT2L2, CACYBP, CDA, CELA2A, CR1, CRABP2, CRCT1, CRNN, CSF-1, CTSS, CYR61, DAP3, DDOST, DTL, E2F2, EDN2, EFNA1, EXO1, HIST2H2BE, IER5, IFI16, IFI6, IL10, ILF2, IVL, JAK1, KCNC4, KIAA1324, LMX1A, MUL1, MYCL1, NRAS, PTGS2, RGS1, RUNX3, S100A10, S100A7, S100A8, S100A9, SFN, SPRR1A, SPRR1B, SPRR2A, SPRR2B, SPRR3, TGFB2, TP73
Chromosome 12	43	A2M, CAMKK2, CCND2, CD63, CDK2, CDKN1B, CHFR, CLEC2B, DDIT3, EMP1, ENDOU, EPS8, GAPDH, GLI1, GLTP, GYS2, HOXC10, HSPB8, IFNG, IGF1, IGFBP6, KITLG, KRAS, KRT1, KRT18, KRT3, KRT4, KRT6B, KRT7, KRT8, LGR5, MDM2, NTF3, NTN4, OAS3, P2RX4, PA2G4, PEBP1, POP5, RAPGEF3, RARG, TBX3, VWF
Chromosome 11	42	APLP2, BANF1, CADM1, CALCA, CCND1, CD44, CRYAB, CTSC, CTSF, FANCF, GSTP1, HRAS, HSPB2, IFITM1, IGF2, IL18, LDHA, MAP3K11, MMP1, MMP10, MMP12, MMP13, MMP3, MRPL11, MYOD1, ORAOV1, PGR, POU2F3, PPP2R1B, RARRES3, RTN3, SAA1, SIPA1, SLC3A2, SPA17, ST14, STARD10, TMEM132A, TRIM29, VEGFB, WT1, YIF1A
Chromosome 5	34	ALDH7A1, APC, BASP1, BRD9, BXDC2, C5orf22, C5orf28, CCNB1, CSF1R, DHFR, DUSP1, FASTKD3 , FGF1, GPX3, HIN-1, ITGA1, NDUFS6, NNT, OSMR, PAIP1, PAPD7, PTTG1, RNASEN, RPL37, SCAMP1, SDHA, SEPP1, SKP2, SPARC, SPINK5, TARS, TERT, TMCO6, TRIP13
Chromosome 17	34	ACADVL, ALOX12, ALOX12B, BIRC5, BRCA1, C1QBP, COL1A1, CUEDC1, ERBB2, GRB2, HIC1, HOXB6, KRT10, KRT13, KRT15, KRT17, KRT19, KRTHA3B, LSMD1, MRPS23, NME1, NME2, NPTX1, PDK2, PECAM1, PHB, PRR11, RARA, STAT3, TIMP2, TMC6, TOB1, TOP2A, TP53
Chromosome 20	34	ADRM1, AHCY, ASXL1, ATP9A, B4GALT5, BCL2L1, C20orf20, C20orf30, CDH4, CEBPB, CSE1L, DDX27, E2F1, EDN3, GSS, LAMA5, MMP9, PAX1, PCNA, PIGT, POFUT1, PTK6, RALY, RBL1, RNF114, SEMG2, STAU1, STX16, SYCP2, TCEA2, TGM3, THBD, TPX2, ZNF217
Chromosome 6	31	CD83, CDC40, CDKN1A, CITED2, CRISP3, CTGF, DEK, E2F3, EDN1, ESR1, GJA1 , GRM4, GTF2H4, HIST1H1C, HLA-C, HLA-DQB1, HLA-DRA, HLA-DRB3, HLA-DRB5, MCM3, ME1, MLLT4, NOL7, NRM, PLAGL1, PSMB9, THBS2, TNF, TREM2, TUBB2, VEGFA
Chromosome 2	30	ANXA4, ATIC, CD28, CXCR2, EPCAM, ERBB4, HDLBP, HSPD1, ICOS, IGFBP2, IGFBP5, IL1A, IL1RN, ITGA4, ITGA6, ITGAV , ITM2C, MAL, MSH2, MYCN, NCL, OSR1, PDCD1, PIGF, RPRM , RRM2, SDC1 , SP100, STAT1, TGFA
Chromosome 16	28	CDH1, CDH11, CDH13, CDH15, CDH3, CES1, CNOT1, CYBA, E2F4, FANCA, FUS, GFOD2, HBA2, HS3ST2, IL32, MMP2, MSLN, MT1G, NAE1, NDRG4, NQO1, PPL, PYCARD, RBL2, RRAD, SLC7A6OS, SOCS1, VPS35
Chromosome 19	28	APOC1, BST2, C3, CCNE1, CEACAM1, CEACAM5, CEACAM6, CEACAM7, DNMT1, GDF15, IRF3, JUNB, KLK10, KLK11, KLK12, KLK13, KLK2, KLK7, KLK8, LGALS7, RPS19, RRAS, STK11, SULT2B1, TGFB1, TYK2, UPK1A, XRCC1
Chromosome 3	27	APOD, BLU, CAMKV, CCR2, CLDN1, CTNNB1, ECT2, FHIT, FOXL2, HLTF, HYAL1, LHFPL4, LSM3, MCM2, MLH1, PCNP, PLOD2, PLSCR1, RAF1, RARB, RASSF1, RBP1, RPL39L, RPSA, TFRC, VHL, ZBED2
Chromosome 4	26	C4orf41, CPE, CWH43, EDNRA, EREG, FGF2 , HOPX, HPGD, IL8, KIT, KLF3, LARP7, MSX1, NEK1, NKX6-1, PCDH10, PDGFRA, PRDM5, S100P, SFRP2, SPP1, TBC1D1, TLR2, TMPRSS11D, TMPRSS11E, VEGFC
Chromosome 7	19	AEBP1, ANLN, BRAF, BZW2, CDK6, EGFR, EZH2, GARS, HOXA1, IGFBP3, IL6, ITGB8, MET, PRSS2, SFRP4, STK31, TFPI2, TRA2A, TWIST1
Chromosome 9	19	ANXA1, AQP3, BAG1, BICD2, CDKN2A, CDKN2B, CKS2, CLIC3, CTSL1, DAPK1, ENG, EPB41L4B , INPP5E, MRPS2, PRSS3, RCL1, SYK, TGFBR1, TLR4
Chromosome 10	16	ANXA8, ARHGAP12, BNIP3, CPEB3, DNAJC9, FGFR2, GATA3, ITGB1, MGMT, NEBL, OAT, PDCD4, PPP1R3C, PTEN, SCD, SFRP5
Chromosome 8	14	ADAM9, DLC1, DUSP26, E2F5, LY6D, LYPLA1, MCM4, MYC, NDRG1, PLAT, SFRP1, SLURP1, SULF1, TNFRSF10C
Chromosome 15	13	ANXA2, C15orf48, CPEB1, CTSH, DUT, FGF7, IMP3, MEF2A, ONECUT1, PDIA3, RHCG, THBS1, TSPAN3
Chromosome 13	10	C13ORF18, CCNA1, FLT1, GTF2F2, HMGB1, IPO5, MBNL2, PTPN6, SCEL, SOX1
Chromosome 18	10	BCL2, CDH2, DSG1, DSG2, EPB41L3, NOL4, SERPINB5, SMAD2, SMAD4, TYMS
Chromosome 22	10	APOL2, ARHGAP8, CELSR1, DMC1, KCNJ4, MCM5, MMP11, MYH9, TIMP3, UFD1L
Chromosome 14	8	AKT1, ANG, BCL2L2, ESR2, HSP90AA1, MMP14, SERPINA3, SIX1
Chromosome X	8	FLNA, HUWE1, MSN, PLP2, TIMP1, TKTL1, TLR8, VSIG4
Chromosome 21	5	DNMT3L, ITGB2, PWP2H, RUNX1, TFF3

5.Comparison with other cancer databases

Name of Databases	Number of common genes	Number of unique genes
Lung Cancer Database (HLungDB)	293 (Genes confirmed in Lung Cancer)	244
Human Prostate Gene Database (HPGD)	35	502
Network of Cancer Genes (NCGs)	61	476
Dragon Database of Genes Implicated in Esophageal Cancer (DDEC)	105	432
Dragon Database for Exploration of Ovarian Cancer Genes (DDOC)	70	467

6.Conservation pattern of 537 genes according to Homologene Database.