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Cell lines information from other databasesDraw StructureBatch SubmissionDesign Analog


Cell lines information from other databases

Cell LineDrug Assayed (CancerDR Link)CCLE/COSMIC LinkPCMdb Link
ASPC124CCLEASPC1
BXPC320CCLEBXPC3
BXPC398COSMICBXPC3
CAPAN198COSMICCAPAN1
Capan224CCLECapan2
Capan298COSMICCapan2
HPAFII119COSMICHPAFII
HPAFII21CCLEHPAFII
HuPT324CCLEHuPT3
HuPT398COSMICHuPT3
HuPT498COSMICHuPT4
HuPT423CCLEHuPT4
KP4118COSMIC--
KP424CCLE--
MIAPaCa224CCLEMIAPaCa2
MIAPaCa298COSMICMIAPaCa2
MZ1PC138COSMIC--
PANC0327122COSMICPANC0327
PANC032724CCLEPANC0327
PANC081398COSMICPANC0813
PANC1005122COSMICPANC1005
PANC100524CCLEPANC1005
PSN1158COSMICPSN1
PSN120CCLEPSN1
SW1990121COSMICSW1990
SW199023CCLESW1990
YAPC98COSMIC--


Draw Structure

This tool allow user to draw chemical structure of their molecule by using JME editor. At one time user can predict drug sensitivity on maximum of 16 pancreatic cancer cell lines. It is very difficult to define the cut-off IC50 value, which discriminate sensitive and resistance cancer cell lines. So, we provided an option of IC50 cut-off value, which will be define by the user on the basis of their experimental criteria. On submission, DiPCell returns with logIC50 values on pancreatic cancer cell line chose by the user and with an option to calculate chemical descriptors of the query molecule.

Batch Submission

Sometimes users have more than one molecule to analyse, so we developed batch submission, where user can submit their molecules. Users have to choose the cell lines on which they want to test their query molecules along with the cut-off IC50 value.

Design Analogs

In medicinal chemistry, it is always often that analog of certain molecule is more active than parent one. So, it is a common practice to identify a better molecule of a certain existing drug by structural activity relationship (SAR). In DiPCell, we have incorporated the same kind of a module, where user can design analogs and simultaneously predict their drug sensitivity on pancreatic cancer cell lines. Further, user can choose the best analog and generate their analogs for further refinements. User has to provide scaffold structures, building blocks and linkers as input for this module.