| HMRbase accession number | 22956 |
| Swiss-prot Accession number | O02671 (Sequence in FASTA format) |
| Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: CD_antigen=CD295;Precursor |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. |
| Tissue Specificity | Kidney, liver, spleen, lung, brain, testis, uterus, ovary, corpus luteum, theca and granulosa cells. |
| Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation (By similarity). |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3 (By similarity). Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). |
| Protein Length | 1165 Amino acids |
| Molecular weight | 132523 |
| Domain Name | fn3 Lep_receptor_Ig |
| References | 1 PubMed abstract 10911396
2 PubMed abstract 9800339
3 PubMed abstract 9069130
|
| Hormone | Q29406 Detail in HMRbase
|
| Gene ID | 396836 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors