A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20970 |
| Swiss-prot Accession number | O08725 (Sequence in FASTA format) |
| Description | Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasingpeptide receptor) (GHRP) (Ghrelin receptor). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity). |
| Protein Length | 364 Amino acids |
| Molecular weight | 40963 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 9092793 2 PubMed abstract 9437732 3 PubMed abstract 10604470 |
| Hormone | Q9QYH7 Detail in HMRbase |
| Gene ID | 84022 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |