A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11572 |
| Swiss-prot Accession number | P00796 (Sequence in FASTA format) |
| Description | Renin-2; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Alternative Name: Submandibular gland renin;Contains: Renin-2 heavy chain;Contains: Renin-2 light chain;Precursor |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the peptidase A1 family. |
| Tissue Specificity | Submandibular gland |
| Post translational modification | N/A |
| Function | Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood. |
| Protein Length | 401 Amino acids |
| Molecular weight | 44283 |
| References | 1 PubMed abstract 6812055 2 PubMed abstract 6283373 3 PubMed abstract 15489334 4 PubMed abstract 6089205 5 PubMed abstract 2691339 6 PubMed abstract 6392850 7 PubMed abstract 6357783 8 PubMed abstract 1608447 |
| Domain Name | A1_Propeptide Asp |
| Hormone Name | Renin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | Q9CYN9 Detail in HMRbase |
| Gene ID | 19702 |
| PDB ID | 1SMR |
| Drugpedia | wiki |
| Comments |