A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 11571 |
| Swiss-prot Accession number | P06281 (Sequence in FASTA format) |
| Description | Renin-1; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Alternative Name: Kidney renin;Precursor |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted (By similarity). Membrane (By similarity). Note=Associated to membranes via binding to ATP6AP2 (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the peptidase A1 family. |
| Tissue Specificity | Kidney |
| Post translational modification | N/A |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Protein Length | 402 Amino acids |
| Molecular weight | 44343 |
| References | 1 PubMed abstract 6370686 2 PubMed abstract 2685761 3 PubMed abstract 2691339 4 PubMed abstract 16141072 5 PubMed abstract 15489334 6 PubMed abstract 6089205 7 PubMed abstract 6392850 8 PubMed abstract 9030738 9 PubMed abstract 6327270 |
| Domain Name | A1_Propeptide Asp |
| Hormone Name | Renin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | Q9CYN9 Detail in HMRbase |
| Gene ID | 19701 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |