A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11579 |
| Swiss-prot Accession number | P08424 (Sequence in FASTA format) |
| Description | Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted (By similarity). Membrane (By similarity). Note=Associated to membranes via binding to ATP6AP2 (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the peptidase A1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Protein Length | 402 Amino acids |
| Molecular weight | 44276 |
| References | 1 PubMed abstract 3287330 2 PubMed abstract 3039496 3 PubMed abstract 3047403 4 PubMed abstract 8490598 5 PubMed abstract 15489334 |
| Domain Name | A1_Propeptide Asp |
| Hormone Name | Renin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | Q6AXS4 Detail in HMRbase |
| Gene ID | 24715 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |